Ignite Creation Date:
2024-05-05 @ 12:04 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00230659
Status:
COMPLETED
Last Update Posted:
2023-09-28
First Post:
2005-09-29
Brief Title:
Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
Investigation of Coagulation Parameters in Hereditary Haemorrhagic
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We will address coagulation parameters in hereditary haemorrhagic telangiectasia HHT compared to controls
Detailed Description:
The inherited disease hereditary haemorrhagic telangiectasia HHT causes bleeding from dilated fragile vessels particularly in the nose and gut However many HHT patients develop deep venous thromboses andor pulmonary embolism necessitating treatments with anticoagulants that further impair control of their haemorrhagic state Our initial observations using general coagulation tests suggest that the blood of HHT patients is intrinsically hypercoagulable
We hypothesize that the genetically-determined abnormality in the blood vessels of HHT patients leads to alteration in the concentrations or activity of one or several of the proteins which affect blood clotting leading to a hypercoagulable state
We propose to study levels and activity of blood coagulation factors in people with hereditary haemorrhagic telangiectasia and in normal volunteers This should define the significance and basis for our initial observations and will have significant implications for the clinical management of HHT patients
We hypothesize that the genetically-determined abnormality in the blood vessels of HHT patients leads to alteration in the concentrations or activity of one or several of the proteins which affect blood clotting leading to a hypercoagulable state
We propose to study levels and activity of blood coagulation factors in people with hereditary haemorrhagic telangiectasia and in normal volunteers This should define the significance and basis for our initial observations and will have significant implications for the clinical management of HHT patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None