Ignite Creation Date:
2024-05-05 @ 12:05 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00237471
Status:
TERMINATED
Last Update Posted:
2011-07-21
First Post:
2005-10-10
Brief Title:
Impact of Tight Glycaemic Control in Acute Myocardial Infarction
Sponsor:
Melbourne Health
Organization:
Melbourne Health
Study Overview
Official Title:
Impact of Tight Glycaemic Control With Insulin on Novel Vascular Disease Risk Factors and Myocardial Function and Perfusion in Acute Myocardial Infarction Patients With Hyperglycaemia
Status:
TERMINATED
Status Verified Date:
2011-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
difficulty recruiting patients
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine whether tight glycaemic control with insulin improves myocardial function and myocardial perfusion measured by myocardial contrast echocardiography and novel vascular risk factors in patients with acute myocardial infarction and hyperglycaemia
Detailed Description:
We will randomise patients with acute myocardial infarction and blood glucose levels BGLs 10mmolL within 24 hours of pain onset to either tight glucose control aiming BGLs 45 - 7mmolL with an insulin infusion for 24 hours followed by subcutaneous insulin or standard control BGL 6 - 12mmolL without the use of an insulin infusion Serial myocardial contrast echocardiography will measure changes in myocardial perfusion and function from baseline to 3 months between each group We will also measure changes in inflammatory and endothelial markers over this time to see whether tight glucose control improves these surrogate endpoints
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| GEENA | None | None | None |