Ignite Creation Date:
2024-05-05 @ 12:05 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00234260
Status:
TERMINATED
Last Update Posted:
2008-07-16
First Post:
2005-10-04
Brief Title:
Family Blood Pressure Program - GENOA Genetic Epidemiology Network of Atherosclerosis
Sponsor:
The University of Texas Health Science Center Houston
Organization:
The University of Texas Health Science Center Houston
Study Overview
Official Title:
Family Blood Pressure Program - GENOA Genetic Epidemiology Network of Atherosclerosis
Status:
TERMINATED
Status Verified Date:
2005-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
GENOA the Genetic Epidemiology Network of Arteriopathy consists of a network of three field centers and biochemical and genetic core labs to study the common polymorphic genetic variations to determine individual differences in blood pressure and essential hypertension in 1500 sibling pairs in three racial groups Linkage analyses are performed using an extensive array of candidate genes and anonymous markers throughout the genome
Detailed Description:
Each collaborating investigator is responsible for an essential element of the network Eric Boerwinkle for genotyping and linkage analyses Robert Ferrell for genotyping Craig Hanis for recruiting Mexican-Americans Richard Hutchinson for recruiting African-Americans Sharon Kardia for cladistic and prediction analyses and data management and Stephen Turner for recruiting Non-Hispanic whites and measuring physiologic variables Between 1995 and 2000 the network carried out five specific aims to localize and characterize the genetic determinants of high blood pressure Aim 1 used robust sibling pair linkage methods in 500 hypertensive sibling pairs in each racial group a total of 1500 sibling pairs to localize genes influencing interindividual differences in the occurrence of essential hypertension Aims 2 and 3 took advantage of previously collected blood pressure and intermediate predictor trait data from 1488 normotensive sibling pairs from the Rochester Family Heart Study to localize genes contributing to essential hypertension The linkage analyses Aims 1-3 used both an extensive array of candidate genes and a large number of anonymous markers throughout the genome Aim 4 used multiple diallelic sequence polymorphisms and cladistic analyses within a linked gene to identify haplotypes for further DNA sequencing in order to identify candidate functional DNA sequence variation contributing to interindividual differences in BP levels and essential hypertension status Aim 5 evaluated the ability of candidate functional DNA sequence variation to predict essential hypertension status in the three racial groups
The study was renewed in September 2000 to pursue two lines of investigation The first is to identify and characterize genes contributing to atherosclerotic coronary heart disease using electron beam computed tomography EBCT to quantify coronary artery calcification as a measure of preclinical disease Robust sibling-pair linkage methods will be used to determine whether any of the more than 375 highly polymorphic tandem repeat marker loci spanning the genome are linked to genes influencing EBCT measures of coronary artery calcification in at least 500 GENOA sibships from Rochester Minnesota Association analysis will be used to determine whether biallelic markers of DNA sequence variation in candidate genes identified by GENOA or others to influence blood pressure level or diagnostic category also influence EBCT measures of coronary artery calcification in at least 500 GENOA participants from Rochester Minnesota The second line of investigation extends analytical methods linkage disequilibrium regression and combinatorial partitioning to more finely localize positional candidate genes and loci and to identify gene-gene and gene-environment interaction effects influencing the measured Family Blood Pressure Program and GENOA phenotypes
The study was renewed in September 2000 to pursue two lines of investigation The first is to identify and characterize genes contributing to atherosclerotic coronary heart disease using electron beam computed tomography EBCT to quantify coronary artery calcification as a measure of preclinical disease Robust sibling-pair linkage methods will be used to determine whether any of the more than 375 highly polymorphic tandem repeat marker loci spanning the genome are linked to genes influencing EBCT measures of coronary artery calcification in at least 500 GENOA sibships from Rochester Minnesota Association analysis will be used to determine whether biallelic markers of DNA sequence variation in candidate genes identified by GENOA or others to influence blood pressure level or diagnostic category also influence EBCT measures of coronary artery calcification in at least 500 GENOA participants from Rochester Minnesota The second line of investigation extends analytical methods linkage disequilibrium regression and combinatorial partitioning to more finely localize positional candidate genes and loci and to identify gene-gene and gene-environment interaction effects influencing the measured Family Blood Pressure Program and GENOA phenotypes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None