Ignite Creation Date:
2024-05-05 @ 12:05 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00249314
Status:
UNKNOWN
Last Update Posted:
2007-04-19
First Post:
2005-11-03
Brief Title:
Mol-SHARE Molecular Study of Health Assessment and Risk in Ethnic Groups
Sponsor:
Hamilton Health Sciences Corporation
Organization:
McMaster University
Study Overview
Official Title:
A Prospective Cross-Sectional Case-Control Molecular Study of Health Assessment and Risk in Ethnic Groups
Status:
UNKNOWN
Status Verified Date:
2007-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to directly compare the body composition body fat distribution and morphological and functional features of adipose tissue and skeletal muscle between South Asians and European Caucasians
Detailed Description:
Excess body fat the hallmark of obesity is a major risk factor for the development of insulin resistance decreased insulin sensitivity type 2 diabetes and cardiovascular disease Previous studies have shown that South Asians people who originate from the Indian subcontinent appear particularly prone to develop diabetes and heart disease compared to white Caucasians of European origin In Canada in the Study of Health Assessment and Risk in Ethnic groups SHARE it was observed that in a random selection of South Asian and European individuals South Asians had twice as much type 2 diabetes and cardiovascular disease and were significantly more insulin resistant than Europeans despite a similar body mass index BMI and waist circumference It is possible that the increased propensity of South Asians to develop insulin resistance type 2 diabetes and cardiovascular disease is related to greater total body fat andor increased visceral fat in addition to the possible biological differences in adipose tissue and skeletal muscle tissues The primary objective of this study is therefore to determine differences among age sex and BMI-matched people of South Asian and European Caucasian descent in body composition specifically total body fat lean body mass and fat distribution where the fat is stored in the body This study will therefore test the hypothesis that for a similar BMI South Asians have more total body fat and less lean body mass than age and sex-matched European Caucasians The secondary objectives of this study are to look at the differences in the two ethnic groups at a biological level including differences in visceral fat adipose tissue morphology imflammation and adipokine production skeletal muscle fat content fatty acid oxidation and mitochondrial activity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None