Ignite Creation Date:
2024-05-06 @ 9:07 AM
Last Modification Date:
2024-10-26 @ 12:10 PM
Study NCT ID:
NCT02903277
Status:
UNKNOWN
Last Update Posted:
2016-09-16
First Post:
2016-07-21
Brief Title:
National Observatory of Chronic Myeloid Leukemia Adolescent and Young Adults Treated With Tyrosine Kinase Inhibitors in First Intent
Sponsor:
Centre Hospitalier Universitaire de Nice
Organization:
Centre Hospitalier Universitaire de Nice
Study Overview
Official Title:
National Observatory of Chronic Myeloid Leukemia Adolescent and Young Adults Treated With Tyrosine Kinase Inhibitors in First Intent
Status:
UNKNOWN
Status Verified Date:
2016-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The median age of onset of chronic myeloid leukemia CML in chronic phase PC is about 60 years However CML affects all age groups including 18-25 year olds called adult-young adolescents AJA In France there is no record of CML and especially not for this particular population only a European Register of CML in children up to 18 years has been set up under the coordination of Professor Frederic Millot pediatrics CHU Poitiers Malignancies diagnosed in this population usually have characteristics evolution therapeutic strategies with tyrosine kinase inhibitors TKIs are a real therapeutic revolution with an overall survival very significantly augmented but at present only a minority of patients may one day consider a final judgment of treatment AJA are the most exposed patients to the complications the socio-economic repercussions professional and personal of a very long-term treatment But there is little data in the literature concerning this population Two studies show that diagnosis of CML presents with poor prognostic factors high skoal the observed responses are poorer compared to older patients but it is accompanied difference in survival in all cases with a decline of about 70 mois However these studies have focused solely on the patients included in the study receiving optimized treatment is not the standard treatment at the time It is clearly demonstrated that the inclusion in a study brings a benefit to the patient However the majority of AJA are not included in a study The investigators therefore want to describe the AYA population of CML in France and compare the evolution of patients included or not in a protocol The investigators also want to investigate specific issues of the age of these patients as the reproductive desire Indeed while it does not seem to be any risk of teratogenicity for men treated with ITK this risk is clearly established for women and requires specific supported Another important point is that of the quality of life The state of physical and mental health and his feelings physical activity and its limitations and well-being was assessed by the SF-3612 questionnaire The results of this analysis were compared with those already obtained for the general population not representative of Italian adults with cancer sample and adjusted for sex age geographic region marital status and education level There seems to be young people and women who express a feeling more pejorative This does not only covers the frequency of side effects but also on physical activity and well-being the affected population will be noted that that is particularly involved in the social professional and in the development of his personal life The impact of treatment on quality of life must be considered under penalty of seeing the difficulties of compliance But several studies have demonstrated the negative impact of poor adherence in response to treatments
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None