Ignite Creation Date:
2024-05-05 @ 12:06 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00243958
Status:
UNKNOWN
Last Update Posted:
2005-10-25
First Post:
2005-10-23
Brief Title:
Aluminum and Auditory Function in ESRD
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2005-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hearing impairment either clinical or subclinical is a characteristic of some renal disease patients The hearing impairment could be result from specific etiologies or chronic renal failure itself The causes of hearing impairment in renal disease patients ranged from drugs intoxication in both auditory and renal function like gentamycin or isoniazid congenital disease like Alport syndrome or other collagen-defective renal disease or just aging related End-stage renal disease ESRD patients are special in many parts to general population who have hearing impairment First inflammation in ESRD patients is well-documented second they suffered from various underlying diseases which auditory function was potentially impaired third they need to undergo renal replacement therapy either hemodialysis HD or peritoneal dialysis PD to maintain their life Dialysis itself was found to be a cause of hearing impairment too The biochemical change and constitutive inflammation status are thought to be implicated in the pathogenesis of hearing impairment in ESRD patients Aluminum Al is a well-documented heavy metal which predisposes to Alzheimers disease dementia or some neurologic diseases Al intoxication is very rare in general health population but elevated serum Al level is easily found in ESRD patients since they can not excrete Al by damaged kidneys and dialyzers Inner ear per se is a neurologic tissue so if serum Al level in ESRD patients has any association in their haring function needs to be studied
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None