Ignite Creation Date:
2024-05-06 @ 9:09 AM
Last Modification Date:
2024-10-26 @ 12:10 PM
Study NCT ID:
NCT02916147
Status:
UNKNOWN
Last Update Posted:
2016-09-27
First Post:
2016-09-21
Brief Title:
Effect of Different Anesthetics on the Change of Alarmins in Lung Cancer Patients Receiving Pulmonary Lobectomy
Sponsor:
Tianjin Medical University Cancer Institute and Hospital
Organization:
Tianjin Medical University Cancer Institute and Hospital
Study Overview
Official Title:
Comparison of Volatile and IV Anesthesia on the Change of Alarmins in Lung Cancer Patients Receiving Pulmonary Lobectomy
Status:
UNKNOWN
Status Verified Date:
2016-09
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aim to observe and compare the change of alarmins such as high mobility group nucleosome-binding protein-1 HMGN1 high mobility group proteins b1 HMGb1 Interleukin IL-33 and their soluble receptors including soluble toll like receptor 4 sTLR4 and soluble ST2 sST2 during pulmonary lobectomy for cancer patients receiving volatile anesthesia or intravenous anesthesia under one-lung ventilation OLV By which this study will preliminarily evaluate the correlation of alarmins and prognosis as well as the effect of inhalational and intravenous anesthesia on the prognosis of surgical patients
Detailed Description:
During pulmonary lobectomy as a result of OLV and surgical operation patients can suffer from alveolar and systemic inflammatory response Alarmin is endogenous peptide released by white blood cells and epithelial cells when the body undergo danger signal stimulation which can enhance immune response and has a double effect on tumor Some alarmins and their soluble receptors such as HMGN1 HMGb1 IL-33 and their soluble receptors including sTLR4 and sST2 can be used as biomarkers for tumor progression Previous studies have shown that sevoflurane anesthesia can reduce the level of inflammatory cytokines in bronchoalveolar lavage fluid Meanwhile the latest retrospective study indicated that the mortality of cancer patients receiving volatile anesthesia was significantly higher than that of intravenous anesthesia At this stage no study aimed to investigate the change of alarmins in broncho-alveoli and serum during OLV lung surgery and the possible effect of different anesthetics on them Therefore the investigators plan to enroll 40 patients with lung cancer receiving pulmonary lobectomy Patients are randomly divided into sevoflurane volatile anesthesia group and propofol intravenous anesthesia group n20 Perioperative serum and bronchoalveolar lavage from ventilated lung are obtained using ELISA method to assay and compare the changes of alarmins such as HMGN1 HMGb1 IL-33 and their soluble receptors including sTLR4 and sST2 between two groups All the patients will be followed up for 12 months The correlation of alarmins and prognosis as well as the effect of volatile and intravenous anesthesia on the prognosis of patients will be preliminarily evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None