Ignite Creation Date:
2024-05-05 @ 12:06 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00243893
Status:
COMPLETED
Last Update Posted:
2013-10-09
First Post:
2005-10-24
Brief Title:
Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
Sponsor:
University of California San Francisco
Organization:
University of California San Francisco
Study Overview
Official Title:
Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
Status:
COMPLETED
Status Verified Date:
2013-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this pilot study is to investigate the use of minocycline and doxycycline as medical therapy for inoperable or partially treated arteriovenous malformations AVMs and giant aneurysms
Detailed Description:
Arteriovenous malformations AVMs are a treatable cause of stroke in young adults The processes by which AVMs and giant aneurysms grow in size and spontaneously bleed are unknown The primary reason to treat AVMs and aneurysms is to guard against intracranial bleeding
This pilot study will examine the use of two common antibiotics-minocycline and doxycycline-as medical therapy for inoperable or partially treated AVMs and giant aneurysms These drugs which are tetracycline derivatives can reduce the levels of a family of enzymes called matrix metalloproteases that degrade tissue and thereby cause a reduction in the risk of spontaneous bleeding from AVMs or aneurysm-which is the main cause of stroke associated with these disorders The enzymes can contribute to weaknesses in the wall of blood vessels and may increase the risk of the vessel wall rupturing and causing spontaneous bleeding
This trial also will show that taking minocycline and doxycycline over an extended period in this patient population is safe and well tolerated Results from this study could help plan future studies to benefit patients with abnormal blood vessels prone to bleeding in their brains
This pilot study will examine the use of two common antibiotics-minocycline and doxycycline-as medical therapy for inoperable or partially treated AVMs and giant aneurysms These drugs which are tetracycline derivatives can reduce the levels of a family of enzymes called matrix metalloproteases that degrade tissue and thereby cause a reduction in the risk of spontaneous bleeding from AVMs or aneurysm-which is the main cause of stroke associated with these disorders The enzymes can contribute to weaknesses in the wall of blood vessels and may increase the risk of the vessel wall rupturing and causing spontaneous bleeding
This trial also will show that taking minocycline and doxycycline over an extended period in this patient population is safe and well tolerated Results from this study could help plan future studies to benefit patients with abnormal blood vessels prone to bleeding in their brains
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NS034949 | None | None | None |