Ignite Creation Date:
2024-05-05 @ 10:23 AM
Last Modification Date:
2024-10-26 @ 9:03 AM
Study NCT ID:
NCT00002806
Status:
COMPLETED
Last Update Posted:
2016-07-13
First Post:
1999-11-01
Brief Title:
Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial Glioma
Sponsor:
Alliance for Clinical Trials in Oncology
Organization:
Alliance for Clinical Trials in Oncology
Study Overview
Official Title:
PHASE II STUDY OF PREIRRADIATION PCV CHEMOTHERAPY IN PATIENTS WITH SUPRATENTORIAL LOW-GRADE GLIOMAS
Status:
COMPLETED
Status Verified Date:
2016-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
RATIONALE Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die Radiation therapy uses high-energy x-rays to damage tumor cells Combining radiation therapy with chemotherapy may kill more tumor cells
PURPOSE Phase II trial to study the effectiveness of procarbazine lomustine and vincristine followed by radiation therapy in treating adults who have supratentorial glioma
PURPOSE Phase II trial to study the effectiveness of procarbazine lomustine and vincristine followed by radiation therapy in treating adults who have supratentorial glioma
Detailed Description:
OBJECTIVES I Estimate the response rate of patients with newly diagnosed supratentorial low-grade glioma following neoadjuvant chemotherapy with PCV procarbazinelomustinevincristine II Describe the toxicity of PCV III Determine the incidence of disease progression in these patients during PCV treatment
OUTLINE The following acronyms are used CCNU Lomustine NSC-79037 PCB Procarbazine NSC-77213 PCV PCBCCNUVCR VCR Vincristine NSC-67574 3-Drug Combination Chemotherapy Followed by Radiotherapy PCV followed by external-beam cranial irradiation using at least 6 MV photons
OUTLINE The following acronyms are used CCNU Lomustine NSC-79037 PCB Procarbazine NSC-77213 PCV PCBCCNUVCR VCR Vincristine NSC-67574 3-Drug Combination Chemotherapy Followed by Radiotherapy PCV followed by external-beam cranial irradiation using at least 6 MV photons
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| CDR0000064910 | REGISTRY | PDQ Physician Data Query | None |