Ignite Creation Date:
2024-05-05 @ 12:06 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00244517
Status:
TERMINATED
Last Update Posted:
2010-07-01
First Post:
2005-10-25
Brief Title:
DIAFAX III-Effects of Inhalative Anesthetics on Left Ventricular Diastolic Function
Sponsor:
University Hospital Basel Switzerland
Organization:
University Hospital Basel Switzerland
Study Overview
Official Title:
The Effects of Remifentanil Sevoflurane Isoflurane and Desflurane on Left Ventricular Diastolic Function in Humans
Status:
TERMINATED
Status Verified Date:
2010-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Part II was not performed as we could not include enough patients fulfilling the inclusion criteria
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Anaesthetics may impair the diastolic function of the heart but the importance of this finding for patients has not been sufficiently examined Specially the effects on diastolic function in patients with diastolic dysfunction has to be determined The aim of this study is to examine the effect of isoflurane only part I sevoflurane and desflurane part III on the diastolic left ventricular function by doppler echocardiography
Detailed Description:
In part I 60 healthy young subjects free from cardiovascular disease will be examined In part II 50 patients with impaired diastolic but preserved systolic function ie patients with arterial hypertension and ejection fraction 50 Doppler echocardiography will be performed at baseline before induction of anaesthesia during anaesthesia in the spontaneously breathing patient and in the mechanically ventilated patient
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None