Ignite Creation Date:
2024-05-05 @ 12:07 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00259441
Status:
COMPLETED
Last Update Posted:
2007-07-12
First Post:
2005-11-25
Brief Title:
PROMISS Simvastatin Prevents the Contrast Induced Acute Renal Failure in Patients With Renal Insufficiency Undergoing Coronary Angiography
Sponsor:
Seoul National University Hospital
Organization:
Seoul National University Hospital
Study Overview
Official Title:
Prevention of Radiocontrast Media Induced Nephropathy by Short-Term High-Dose Statin in Renal Insufficiency Undergoing Coronary Angiography PROMISS
Status:
COMPLETED
Status Verified Date:
2007-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The contrast induced kidney toxicity has been known to affect the mortality and morbidity in the patients undergoing coronary angiography But the mechanism and therapeutic strategy for it is not well known Nowadays it is reported that the N-acetylcysteine may have preventive effects for contrast induced kidney toxicity with its antioxidant effectsThe statins have been reported to have many other effects other than the lipid lowering effect-including antioxidant effect so we hypothesized that the antioxidant effect of simvastatin may prevent the contrast induced kidney toxicity
Detailed Description:
The simvastatin may prevent the contrast agent induced acute renal failure in the patients with underlying renal insufficiency who is undergoing the coronary angiography The effect may derive from the antioxidant function of simvastatin
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None