Ignite Creation Date:
2024-05-05 @ 10:23 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00007215
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-12-15
Brief Title:
Dynamic Light Scattering Device DLS Study of Age-Related Changes in the Lens and Cataracts
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Study of Age-Related Changes in the Human Lens and Cataracts In Vivo Using Dynamic Light Scattering Device DLS Combined With Keratoscopy
Status:
COMPLETED
Status Verified Date:
2004-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use a newly developed instrument called dynamic light scattering device DLS to examine age-related changes in the human lens and to study the causes and development of cataracts DLS uses a low intensity laser light similar to that used in supermarket checkouts to measures lens cloudiness It detects changes in the human lens at the earliest stages when anti-cataract treatment would be most effective in reversing delaying or preventing cataract formation
Patients 18 years of age and older with cataracts and normal volunteers between the ages of 18 and 70 years may be eligible for this study Participants will have a standard eye examination including a vision check pressure measurement lens examination using DLS and examination of the retina Photographs of the lens or retina or both may be taken
This study does not involve treatment No anti-cataract medications will be given
Patients 18 years of age and older with cataracts and normal volunteers between the ages of 18 and 70 years may be eligible for this study Participants will have a standard eye examination including a vision check pressure measurement lens examination using DLS and examination of the retina Photographs of the lens or retina or both may be taken
This study does not involve treatment No anti-cataract medications will be given
Detailed Description:
Recently a device has been created to determine molecular interactions that occur in the nucleus of the lens called Dynamic Light Scattering Device DLS Preliminary studies have shown its potential in the detection of the earliest changes occurring in cataract at the stage where anticataract treatment would theoretically be most effective in reversing delaying or preventing cataracts A new miniaturized version of this device has been developed by NASA using lower energy lasers and offered for further development and testing at the NEI We recently conducted a pilot study to evaluate the usefulness and reproducibility of this instrument for quantitating lens changes and found good reproducibility We also determined that the most useful parameter to use is mean particle size derived from particle size distribution We therefore propose to conduct a study on changes on the lens due to aging age related changes as well as on the three representative types of cataracts nuclear cortical and PSC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-EI-0051 | None | None | None |