Ignite Creation Date:
2024-05-06 @ 9:35 AM
Last Modification Date:
2024-10-26 @ 12:16 PM
Study NCT ID:
NCT03020732
Status:
COMPLETED
Last Update Posted:
2019-02-11
First Post:
2016-12-30
Brief Title:
Gingival Recession Treatment With Concentrated Growth FactorCGF
Sponsor:
Gazi University
Organization:
Gazi University
Study Overview
Official Title:
Concentrated Growth Factor Membrane Versus Subepithelial Connective Tissue Grafts in Treatment of Multiple Gingival Recession Defects a Split-mouth Randomized Clinical Trial
Status:
COMPLETED
Status Verified Date:
2019-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Platelet concentratesPC are used in the field of periodontology and implantology for the content necessary key cells and growth factors to accelerate healing and to provide regeneration Concentrated Growth FactorsCGF is defined as an innovative method or a new generation PC The purpose of this clinical study was to evaluate the clinical effectiveness of Concentrated Growth FactorCGF membrane with coronally advanced flapCAF procedures and subepithelial connective tissue graftSCTG with CAF in the treatment of Miller class I gingival recessions GR
Detailed Description:
CGF is defined as an innovative method to produce platelet rich fibrinPRF or a new generation platelet concentratePCThe rotational speed of the centrifuge machine used in CGF varies between 2400-3000 rpm The variability of the rotation speed during centrifugation allows a fibrin matrix that larger more intensive and includes more growth factors than PRF Some studies have been reported that CGF have an inducing effect on periodontal ligament stem cells for osteogenic differentiation and clinically provides new bone formation for the sinus augmentation In literature there is only one clinical research associated with multiple gingival recession defects treatment It showed that CGF with CAF surgery increases keratinized gingiva weight and thickness and it maybe prevents post-operative relapse for CAF
PC has also been mentioned to be effective in to increase the width of keratinized tissue with providing root coverage and it may reduce early post-surgical complications and accelerate wound healing in systematic review In the treatment of isolated or multiple gingival recession PRF and SCTG with CAF procedures have been reported to similar root coverage PRF can be used as an alternative method for SCTG CGF and PRF have similar composition However higher resistance and viscosity of CGF may protect growth factors from proteolysis better than PRF There is any comparative study for CGF and SCTG in literature in terms of clinically or patient related parameters
Therefore the purpose of this clinical study is to evaluate the clinical efficacy of CGF in combination with CAF in the treatment of gingival recessions defects and to compare SCTG in combination with CAF It is also aimed to asses and compare postoperative pain and soft tissue healing
PC has also been mentioned to be effective in to increase the width of keratinized tissue with providing root coverage and it may reduce early post-surgical complications and accelerate wound healing in systematic review In the treatment of isolated or multiple gingival recession PRF and SCTG with CAF procedures have been reported to similar root coverage PRF can be used as an alternative method for SCTG CGF and PRF have similar composition However higher resistance and viscosity of CGF may protect growth factors from proteolysis better than PRF There is any comparative study for CGF and SCTG in literature in terms of clinically or patient related parameters
Therefore the purpose of this clinical study is to evaluate the clinical efficacy of CGF in combination with CAF in the treatment of gingival recessions defects and to compare SCTG in combination with CAF It is also aimed to asses and compare postoperative pain and soft tissue healing
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None