Ignite Creation Date:
2024-05-05 @ 9:36 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001329
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Study of Norepinephrine Levels and Sympathetic Nervous System Activity
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Plasma Catecholamine Kinetics
Status:
COMPLETED
Status Verified Date:
2002-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Brain and nerve cells communicate with each other by releasing and picking up chemicals called neurotransmitters Norepinephrine is a neurotransmitter used by part of the nervous system activated during stress called the sympathetic nervous system The sympathetic nervous system is involved with regulating blood pressure and pulse rate Researchers believe the level norepinephrine in the blood can be used to measure activity of the sympathetic nervous system
This study is designed to answer important questions about rates of release of norepinephrine into the blood stream removal of released norepinephrine and the sympathetic nervous system response to stress
Researchers will attempt to measure levels of norepinephrine and activity of the sympathetic nervous system in patients with high blood pressure normal patients with family histories of high blood pressure patients taking drugs that can effect levels of norepinephrine and patients with diseases or conditions directly affecting the sympathetic nervous system
This study is designed to answer important questions about rates of release of norepinephrine into the blood stream removal of released norepinephrine and the sympathetic nervous system response to stress
Researchers will attempt to measure levels of norepinephrine and activity of the sympathetic nervous system in patients with high blood pressure normal patients with family histories of high blood pressure patients taking drugs that can effect levels of norepinephrine and patients with diseases or conditions directly affecting the sympathetic nervous system
Detailed Description:
In order to examine sympathetic nervous system function in neurocardiological disorders and catecholaminergic effects of dietary manipulations or neuropsychiatric drugs the protocol calls for evaluations of the kinetics of 3H-norepinephrine or 3H-epinephrine in patients with hypertension dysautonomias or disorders thought to involve abnormal catecholaminergic function and in normotensive normal volunteers Apparent spillover and clearance rates are estimated based on the norepinephrine or epinephrine concentration during the infusion and their steady-state specific activities under resting conditions and in response to physiological or pharmacological manipulations thought to affect sympathetic outflows
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 92-N-0259 | None | None | None |