Ignite Creation Date:
2024-05-05 @ 12:08 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00257985
Status:
COMPLETED
Last Update Posted:
2006-08-01
First Post:
2005-11-22
Brief Title:
Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2
Sponsor:
Danish Headache Center
Organization:
Danish Headache Center
Study Overview
Official Title:
Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2
Status:
COMPLETED
Status Verified Date:
2005-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion
Detailed Description:
Glyceryl trinitrate GTN induces migraine attacks indistinguishable from spontaneous attacks in approximately 80 of migraine sufferers After systemic administration GTN is transformed to nitric oxide NO Treatment of spontaneous migraine attacks with an inhibitor of NO is effective in 60 of patients These data show that NO is involved in both initiation and maintenance of migraine attack
The consequence of migraine gene mutations on relevant migraine pathways has never been tested The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion The project will improve our understanding of the neurobiology of migraine and stimulate development of new treatment targets
The consequence of migraine gene mutations on relevant migraine pathways has never been tested The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion The project will improve our understanding of the neurobiology of migraine and stimulate development of new treatment targets
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None