Ignite Creation Date:
2024-05-05 @ 12:08 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00250523
Status:
UNKNOWN
Last Update Posted:
2021-03-02
First Post:
2005-11-07
Brief Title:
Mathematical Modeling of the Acute Inflammatory Response Following Injury
Sponsor:
National Institute of General Medical Sciences NIGMS
Organization:
National Institute of General Medical Sciences NIGMS
Study Overview
Official Title:
Mathematical Modeling of the Acute Inflammatory Response Following Injury
Status:
UNKNOWN
Status Verified Date:
2021-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this research study is to gather clinical and biologic information from severely injured patients to better understand and characterize the host response to injury and inflammation across several domains This information may improve outcome prediction improve clinical treatment of injured patients and permit the construction of non-biologic computerized models of illness that can be utilized to represent the host response in future research efforts This study is designed as the calibration of a mathematical model of this response with predictive capabilities
The central hypothesis governing this study is that adaptive immune elements are crucial to determining the outcome of complex inflammatory scenarios We propose to test these hypotheses in the following interrelated Specific Aims
Specific Aim 1 To develop a robust mathematical model describing traumahemorrhage-induced inflammation in humans its pathologic consequences and possible therapies
Specific Aim 2 To translate the mathematical model to humans and create software aimed at individualized clinical decision-making
Specific Aim 3 To determine the prevalence of an IL-1 receptor-associated kinase IRAK-1 variant haplotype located on the X-chromosome in an injured population and to characterize differences in the pro-inflammatory response across gender relative to the IRAK-1 haplotype
Specific Aim 4 To determine if increased arginase activity previously observed in isolated peripheral blood mononuclear cells of trauma patients is a consequence of the presence of contaminating activated granulocytes or a particular subset of an arginase positive monocyte subset
The central hypothesis governing this study is that adaptive immune elements are crucial to determining the outcome of complex inflammatory scenarios We propose to test these hypotheses in the following interrelated Specific Aims
Specific Aim 1 To develop a robust mathematical model describing traumahemorrhage-induced inflammation in humans its pathologic consequences and possible therapies
Specific Aim 2 To translate the mathematical model to humans and create software aimed at individualized clinical decision-making
Specific Aim 3 To determine the prevalence of an IL-1 receptor-associated kinase IRAK-1 variant haplotype located on the X-chromosome in an injured population and to characterize differences in the pro-inflammatory response across gender relative to the IRAK-1 haplotype
Specific Aim 4 To determine if increased arginase activity previously observed in isolated peripheral blood mononuclear cells of trauma patients is a consequence of the presence of contaminating activated granulocytes or a particular subset of an arginase positive monocyte subset
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P50GM053789-09 | NIH | None | httpsreporternihgovquickSearchP50GM053789-09 |