Ignite Creation Date:
2024-05-06 @ 9:41 AM
Last Modification Date:
2024-10-26 @ 12:18 PM
Study NCT ID:
NCT03046745
Status:
UNKNOWN
Last Update Posted:
2020-05-19
First Post:
2017-02-05
Brief Title:
Gastric Cancer Registry for Epidemiology and Molecular Risk Factor
Sponsor:
Kyungpook National University Hospital
Organization:
Kyungpook National University Hospital
Study Overview
Official Title:
Analysis and Prediction of Epidemiology and Molecular Biologic Risks of Gastric Cancer by Multicenter Registry
Status:
UNKNOWN
Status Verified Date:
2020-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is a multi-center prospective cohort study which are planned to enroll the 2500 patients who diagnosed the primary gastric cancer and 5000 healthy normal cohort participants for 5 years All participants who enrolled in this registry the participants were questioned by the gastric cancer survey and the serum and tissue of these participants were analyzed
The main aim of this study is
1 To evaluate the optimal interval of endoscopic screening for early detection of gastric cancer and risk factors in Korean
2 To evaluate the diagnostic validity of serum biomarker combining pepsinogen H pylori IgG Antibody and TFF3 as a screening test for detection of GC in Korean
The main aim of this study is
1 To evaluate the optimal interval of endoscopic screening for early detection of gastric cancer and risk factors in Korean
2 To evaluate the diagnostic validity of serum biomarker combining pepsinogen H pylori IgG Antibody and TFF3 as a screening test for detection of GC in Korean
Detailed Description:
Gastric cancer GC is the fourth most common type of cancer 934 000 new cases 86 of all new cancer cases in 2002 and the second most common cause of cancer death 700 000 deaths annually in the world Several Asian countries including China Japan and Korea have the highest incidences of GC in the world Because the prognosis of early GC is highly favorable high- prevalence countries such as Japan and Korea have sought to reduce the disease burden by providing GC screening to aver- age-risk populations In Korea national GC screening was instituted in 1999 as part of the National Cancer Screening Program NCSP The NCSP recommends biennial GC screening for males and females older than 40 years of age using direct or indirect upper gastrointestinal series UGIS or endoscopy Upper gastrointestinal endoscopies are generally accepted as the gold standard for the diagnosis and clinicopathological evaluation of GC Endoscopic examination has been predominantly used to screen symptomatic individuals and to distinguish patients with GC from those with comparatively benign diseases such as peptic ulcers However there was no consensus for optimal timing of screening endoscopy to detect of early GC
Thus investigators are planned to evaluate the optimal endoscopic interval to find early gastric cancer by use of survey between newly diagnosed GC cohort group and healthy control cohort group In addition investigators are going to analyze the risk factors of GC in Korean epidemiologic diet and clinical factors In this study the investigators are going to enroll the participants who were diagnosed GC and normal control group people from October 2016 to October 2021 in multi-center prospectively The baseline characteristics of the participants H pylori status stage of gastric cancer at diagnosis treatment modalities treatment response and mortality were analyzed
Although diagnosis of gastric cancer has been characterized by endoscopy there has been a strong demand for serologic marker because accessibility invasiveness discomfort of endoscopy In recent years there have been advancements in the molecular biomarkers utilized in the cancer detection and in the development of therapeutic agents based on the target genes for a few types of solid tumours excluding GC With the advancement of molecular biological techniques in the last decades researchers have gained important insights into the oncogenesis mechanisms of GC Besides the well-known pathogenic factor Helicobacter pylori various experimental approaches have identified oncogenes and tumour suppressor genes including cell cycle regulation genes in the growth and signal transduction pathways Recently several studies were reported about the efficacy of the serum biomarker serum PG H pylori Ig G Antibody and TFF3 etc for diagnosis of GC In this present study investigators are going to the efficacy of serum biomarker by the use of serum of GC patients and health control group
Thus investigators are planned to evaluate the optimal endoscopic interval to find early gastric cancer by use of survey between newly diagnosed GC cohort group and healthy control cohort group In addition investigators are going to analyze the risk factors of GC in Korean epidemiologic diet and clinical factors In this study the investigators are going to enroll the participants who were diagnosed GC and normal control group people from October 2016 to October 2021 in multi-center prospectively The baseline characteristics of the participants H pylori status stage of gastric cancer at diagnosis treatment modalities treatment response and mortality were analyzed
Although diagnosis of gastric cancer has been characterized by endoscopy there has been a strong demand for serologic marker because accessibility invasiveness discomfort of endoscopy In recent years there have been advancements in the molecular biomarkers utilized in the cancer detection and in the development of therapeutic agents based on the target genes for a few types of solid tumours excluding GC With the advancement of molecular biological techniques in the last decades researchers have gained important insights into the oncogenesis mechanisms of GC Besides the well-known pathogenic factor Helicobacter pylori various experimental approaches have identified oncogenes and tumour suppressor genes including cell cycle regulation genes in the growth and signal transduction pathways Recently several studies were reported about the efficacy of the serum biomarker serum PG H pylori Ig G Antibody and TFF3 etc for diagnosis of GC In this present study investigators are going to the efficacy of serum biomarker by the use of serum of GC patients and health control group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None