Ignite Creation Date:
2024-05-06 @ 9:42 AM
Last Modification Date:
2024-10-26 @ 12:18 PM
Study NCT ID:
NCT03051308
Status:
UNKNOWN
Last Update Posted:
2017-02-13
First Post:
2017-01-29
Brief Title:
University of Wisconsin Solution Versus New Parathyroid Transport Solution for Parathyroid Allotransplantation
Sponsor:
SB Istanbul Education and Research Hospital
Organization:
SB Istanbul Education and Research Hospital
Study Overview
Official Title:
University of Wisconsin Solution Versus New Parathyroid Transport Solution for Parathyroid Allotransplantation Effects on Calcium Sensing and Vitamin D Receptor During Cold Ischemia
Status:
UNKNOWN
Status Verified Date:
2017-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Compare the functionality of new parathyroid transport solution NPTS with University of Wisconsin Solution UW on parathyroid glands Also assess its effects on cell viability parathormone PTH secretion calcium-sensing receptor CaSR and vitamin D receptor VDR levels during cold ischemia
Detailed Description:
Parathormone PTH and vitamin D are two critical hormonal regulators of calcium homeostasis There is an important relationship between the PTH release and vitamin D receptor for controlling hormonal systems Also calcium-sensing receptor plays a crucial role in regulating parathormone secretion which means controlling the calcium-dependent systemic ion homeostasis
Cold ischemia protects organs and tissues by slowing their metabolism The cold ischemia of the transplant tissue is a very important process The University of Wisconsin UW solution substantially improves graft preservation and consequently increases patient survival The researchers newly developed NPTS for transportation of parathyroid glands
For the comparision the researchers measured the parathyroid cell viability and the calcium sensing and vitamin D receptor density of the parathyroid cells at the 0 6 12 and 24 hours of cold ischemia
Cold ischemia protects organs and tissues by slowing their metabolism The cold ischemia of the transplant tissue is a very important process The University of Wisconsin UW solution substantially improves graft preservation and consequently increases patient survival The researchers newly developed NPTS for transportation of parathyroid glands
For the comparision the researchers measured the parathyroid cell viability and the calcium sensing and vitamin D receptor density of the parathyroid cells at the 0 6 12 and 24 hours of cold ischemia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None