Ignite Creation Date:
2024-05-05 @ 12:09 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00257231
Status:
COMPLETED
Last Update Posted:
2019-03-07
First Post:
2005-11-18
Brief Title:
Inflammation and the Host Response to Injury Trauma
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
Inflammation and the Host Response to Injury
Status:
COMPLETED
Status Verified Date:
2019-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to help improve our understanding of the biology involved in the bodys response to serious trauma or burn injury The host response to trauma and burns is a collection of physiological and pathophysiological processes that depend critically upon the regulation of the human innate immune system with particular emphasis on the inflammatory component of that system No single research center or small group of centers has the capacity to delineate the integrated response of this complex biological system which involves multiple molecular and genetic interactions that vary in time Our proposal promotes the identification of important dynamic relationships that regulate the integration of this complex biological system with the expectation that this understanding will ultimately impact the diagnosis prognosis and treatment of the hospitalized severely injured patient
Detailed Description:
This large-scale collaborative project provides the means to acquire the necessary new knowledge directly in humans Knowledge will be acquired using diverse state-of-the-art genomic and proteomic technologies a highly complex clinical proteomic and genomic database as well as newly-developed novel analytical tools to probe this complex dataset Our analytical capabilities at the genomic and proteomic level are now rapidly evolving and our ability to link these genomic and proteomic data to pathways and functional modules will help us more closely link this cellular data to immunological processes and ultimately to the phenotypic response ie trajectory in the injured host As a result potential interventions whether through our Program or other funding mechanisms can be more effectively designed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U54GM062119 | NIH | None | httpsreporternihgovquickSearchU54GM062119 |