Ignite Creation Date:
2024-05-05 @ 12:09 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00250224
Status:
COMPLETED
Last Update Posted:
2015-06-26
First Post:
2005-11-07
Brief Title:
Prostate Localization During Radiotherapy Using a Ni-Ti Stent and Electronic Portal Imaging - Protocol II
Sponsor:
Aalborg University Hospital
Organization:
Aalborg University Hospital
Study Overview
Official Title:
Prostate Localization During Radiotherapy Using a Ni-Ti Stent and Electronic Portal Imaging - Protocol II
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A new method for localization of the prostate during external beam radiotherapy The method is based on insertion of a new thermo-expandable Ni-Ti stent The radiological properties of the stent are used for precise prostate localization during treatment using electronic portal images
Detailed Description:
Inclusion criterias in the study were 1 Patients should present with histological verified local or locally advanced PC stage T2b to T3b N0 M0 UICC 1992 classification was used 2 Patients should consequently be candidates for intended curative radiotherapy Prostatic work up is done before inclusion in the study A new prostatic Nickel - Titanium stent is placed in the prostatic urethra one week prior to the radiotherapy planning CT using a flexible cystoscope to insert the stent under urethral anaesthesia The stent is then flushed with hot water 60 degrees Celsius The hot water expands the stent collar thereby locking the stent in place Correct positioning of the stent is secured visually on retraction of the scope Radiotherapy of prostate is given to a mean dose of 70 department standard regime Treatment are given with daily fractions of 2 Gy using a combination of 6 MV and 18 MV X-ray fields using isocentric 3D conformal treatment plan consisting of three MLC conformal radiation fields One anterior and two lateral wedged fields This was assumed to be the optimal treatment plan A pair of orthogonal 15 cm x 15 cm isocenter setup fields was added to the plan The orthogonal fields are used to obtain pairs of electronic portal images Electronic portal images are recorded using a Varian As500 electronic portal imaging device EPID The images are used to determine the 3D reference position of the stent The image pairs of the stent were taken at eight treatment sessions in each patient Session number 1236112122 and 23 From each orthogonal set of images the 3D position of both the stent and the symphysis pubic bone are determined Positions are calculated using orthogonal reconstruction A control CT scan is made before treatment session number 21 to verify the intra prostatic position of the stent The intra prostatic position of the stent is also verified during removal of the stent three months after radiation therapy Before removal the stent was flushed with water at 10 degrees Celsius When cooled with 10C cold water the stent became super soft and can easily be removed as a twisted wire
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None