Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005316
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
White Coat Hypertension and Antihypertensive Treatment Effect - SCOR in Hypertension
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the mechanisms of white coat hypertension and study it further as a risk factor for heart damage
Detailed Description:
BACKGROUND
The multidisciplinary SCOR examined causes consequences and treatments of human hypertension A central theme was the renal basis for human hypertension The subproject on white coat hypertension began in December of 1985
DESIGN NARRATIVE
In the longitudinal study eighty patients with white coat hypertension were compared with 40 age- and sex-matched normotensives and with 80 patients with sustained hypertension The protocol consisted of a clinic blood pressure measurements made both by a physician and a nurse b self-monitoring at home c noninvasive ambulatory monitoring d reactivity testing cold pressor test mental arithmetic and isometric exercise and e Korotkoff signal recording Patients were also tested for early markers of disease echocardiography and urine albumin
The 80 patients in each of the two hypertensive groups were randomized to one of four treatment protocols 20 patients each an alpha blocker a beta blocker a combined alpha- and beta-blocker or an ACE inhibitor The doses of medication were adjusted to produce similar reductions of clinic blood pressure in the different groups The test battery a-e was reported during treatment
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The multidisciplinary SCOR examined causes consequences and treatments of human hypertension A central theme was the renal basis for human hypertension The subproject on white coat hypertension began in December of 1985
DESIGN NARRATIVE
In the longitudinal study eighty patients with white coat hypertension were compared with 40 age- and sex-matched normotensives and with 80 patients with sustained hypertension The protocol consisted of a clinic blood pressure measurements made both by a physician and a nurse b self-monitoring at home c noninvasive ambulatory monitoring d reactivity testing cold pressor test mental arithmetic and isometric exercise and e Korotkoff signal recording Patients were also tested for early markers of disease echocardiography and urine albumin
The 80 patients in each of the two hypertensive groups were randomized to one of four treatment protocols 20 patients each an alpha blocker a beta blocker a combined alpha- and beta-blocker or an ACE inhibitor The doses of medication were adjusted to produce similar reductions of clinic blood pressure in the different groups The test battery a-e was reported during treatment
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P50HL018323 | NIH | None | httpsreporternihgovquickSearchP50HL018323 |