Ignite Creation Date:
2024-05-05 @ 12:09 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00260468
Status:
COMPLETED
Last Update Posted:
2009-10-22
First Post:
2005-11-30
Brief Title:
Brain Abnormalities in Late-Onset Major Depression
Sponsor:
University of Aarhus
Organization:
University of Aarhus
Study Overview
Official Title:
Structural and Functional Cerebral Findings in Late-Onset Major Depression
Status:
COMPLETED
Status Verified Date:
2009-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of this project is to examine the state of the brain in people over 50 years old suffering from late-onset depression by means of an extensive clinical assessment programme including magnetic resonance imaging MRI neuropsychological testing neurological examination eye examination as well as blood and saliva samples The results are to be compared with results from a control group matched for gender and age
Detailed Description:
Major depression is a frequent and serious disorder with different prognoses and complications with respect to lack of treatment response recurrence and suicide
MRI of the brain can provide information about changes in the brain tissue with depression eg lesions of nerve connections small thrombi or changes in the blood flow These changes appear primarily after the age of 50 and are seen in cases of diabetes and high blood pressure Furthermore the connection between disruptions in the bodys stress response system and depression will be explored which is very important since studies indicate that stress and depression can affect certain brain parts permanently This will give us a better understanding of the connection between brain changes neuropsychology and depression prognosis which is decisive for accurate diagnostics effective treatment and targeted prevention of the disease in the long run
The project is part of a larger clinical assessment programme in the Neuropsychiatric Unit under the Centre for Basic Psychiatric Research Aarhus Psychiatric Hospital Denmark which gives us unique possibilities of combining research and daily clinical work The hope is in the future to be able to offer patients in the risk group better assessment and treatment to prevent complications and recurrence
MRI of the brain can provide information about changes in the brain tissue with depression eg lesions of nerve connections small thrombi or changes in the blood flow These changes appear primarily after the age of 50 and are seen in cases of diabetes and high blood pressure Furthermore the connection between disruptions in the bodys stress response system and depression will be explored which is very important since studies indicate that stress and depression can affect certain brain parts permanently This will give us a better understanding of the connection between brain changes neuropsychology and depression prognosis which is decisive for accurate diagnostics effective treatment and targeted prevention of the disease in the long run
The project is part of a larger clinical assessment programme in the Neuropsychiatric Unit under the Centre for Basic Psychiatric Research Aarhus Psychiatric Hospital Denmark which gives us unique possibilities of combining research and daily clinical work The hope is in the future to be able to offer patients in the risk group better assessment and treatment to prevent complications and recurrence
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None