Ignite Creation Date:
2024-05-05 @ 12:10 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00260286
Status:
COMPLETED
Last Update Posted:
2005-12-05
First Post:
2005-11-30
Brief Title:
Effects of Gynecological Age on LH Sensitivity to Energy Availability
Sponsor:
Ohio University
Organization:
Ohio University
Study Overview
Official Title:
Dietary Energy Requirements in Physically Active Men and Women Objective 4B Effects of Gynecological Age on LH Sensitivity to Energy Availability
Status:
COMPLETED
Status Verified Date:
2005-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this experiment is to investigate whether the dependence of luteinizing hormone pulsatility on energy availability declines during adolescence
Detailed Description:
The incidence of menstrual disorders declines during adolescence This has long been attributed to the gradual maturation of the hypothalamic-pituitary-ovarian axis but the mechanism of this maturation is not known Ovarian function critically depends on the pulsatile secretion of gonadotropin-releasing hormone GnRH by the hypothalamus and on the consequent and more readily assessed pulsatility of luteinizing hormone LH secretion by the pituitary LH pulsatility has been shown to depend on energy availability operationally defined as dietary energy intake minus exercise energy expenditure The effects of energy availability on LH pulsatility are thought to be mediated by certain metabolic substrates and hormones
Comparison By manipulating diet and exercise regimens contrasting energy availability treatments of 10 and 45 kilocalories per kilogram of fat-free mass per day are being administered to adolescents with 5-8 years of gynecological age and to adults with 14-18 years of gynecological age for five days in the early follicular phase of separate menstrual cycles Effects of low energy availability on LH pulsatility and on selected metabolic substrates and hormones are being measured
Comparison By manipulating diet and exercise regimens contrasting energy availability treatments of 10 and 45 kilocalories per kilogram of fat-free mass per day are being administered to adolescents with 5-8 years of gynecological age and to adults with 14-18 years of gynecological age for five days in the early follicular phase of separate menstrual cycles Effects of low energy availability on LH pulsatility and on selected metabolic substrates and hormones are being measured
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DAMD_17-95-1-5053 | None | None | None |
| M01RR000034 | NIH | None | httpsreporternihgovquickSearchM01RR000034 |