Ignite Creation Date:
2024-05-05 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00268450
Status:
TERMINATED
Last Update Posted:
2018-07-12
First Post:
2005-12-20
Brief Title:
Cisplatin Bevacizumab and Gemcitabine Followed by Surgery Bevacizumab and Paclitaxel in Treating Patients With Locally Advanced Nonmetastatic Bladder Cancer That Can Be Removed By Surgery
Sponsor:
Medical University of South Carolina
Organization:
Medical University of South Carolina
Study Overview
Official Title:
A Phase II Study of Neo-Adjuvant Cisplatin Gemcitabine Bevacizumab Followed by Radical Cystectomy for Patients With Muscle Invasive Resectable Non-Metastatic Transitional Cell Carcinoma TCC of the Bladder
Status:
TERMINATED
Status Verified Date:
2018-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
RATIONALE Drugs used in chemotherapy such as cisplatin gemcitabine and paclitaxel work in different ways to stop the growth of tumor cells either by killing the cells or by stopping them from dividing Monoclonal antibodies such as bevacizumab can block tumor growth in different ways Some find tumor cells and kill them or carry tumor-killing substances to them Others interfere with the ability of tumor cells to grow and spread Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor Giving combination chemotherapy together with bevacizumab before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed Giving these treatments after surgery may kill any tumor cells that remain after surgery
PURPOSE This phase II trial is studying how well giving cisplatin bevacizumab and gemcitabine followed by surgery bevacizumab and paclitaxel works in treating patients with locally advanced nonmetastatic bladder cancer that can be removed by surgery
PURPOSE This phase II trial is studying how well giving cisplatin bevacizumab and gemcitabine followed by surgery bevacizumab and paclitaxel works in treating patients with locally advanced nonmetastatic bladder cancer that can be removed by surgery
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| MUSC-CTO-100892 | None | None | None |
| MUSC-AVF-3312 | None | None | None |
| MUSC-HR-15537 | None | None | None |
| GENENTECH-AVF-3312 | None | None | None |