Ignite Creation Date:
2024-05-05 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00272571
Status:
COMPLETED
Last Update Posted:
2006-01-31
First Post:
2006-01-04
Brief Title:
The Effects of External Counter Pulsation Therapy on Circulating Endothelial Progenitor Cells
Sponsor:
Sheba Medical Center
Organization:
Sheba Medical Center
Study Overview
Official Title:
The Effects of External Counter Pulsation Therapy ECPT on the Number and Function of Circulating Endothelial Progenitor Cells in Patients With Angina Pectoris
Status:
COMPLETED
Status Verified Date:
2006-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objectives of the study are to test the hypothesis that external counter pulsation therapy ECPT provides clinical benefit by improving the number and function of endothelial progenitor cells EPCs in peripheral blood of patients with angina pectoris
Detailed Description:
ECPT is a non-invasive approach for increasing blood flow to the heart in patients with myocardial ischemia ECPT produces beneficial effects in coronary artery disease CAD patients However the exact mechanisms of ECPT action are not defined yet Evidence has now accumulated that bone marrow-derived cells with angiogenic capability termed EPCs circulate in the blood of adults EPCs possess the ability to home to sites of ischemia and contribute to neoangiogenesis
We prospectively study CAD patients Canadian Cardiovascular Society CCS angina class II-IV before and after ECPT and compare them with age- and sex-matched controls Peripheral blood CD34 cells EPCs CD34VEGFR2 cells EPC colony forming units CFUs and brachial artery endothelial function is assessed prior to and after ECPT Percent improvement in endothelium-dependent brachial artery flow-mediated dilatation FMD is assessed using high-resolution ultrasound
We prospectively study CAD patients Canadian Cardiovascular Society CCS angina class II-IV before and after ECPT and compare them with age- and sex-matched controls Peripheral blood CD34 cells EPCs CD34VEGFR2 cells EPC colony forming units CFUs and brachial artery endothelial function is assessed prior to and after ECPT Percent improvement in endothelium-dependent brachial artery flow-mediated dilatation FMD is assessed using high-resolution ultrasound
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None