Ignite Creation Date:
2024-05-05 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00274391
Status:
COMPLETED
Last Update Posted:
2006-01-10
First Post:
2006-01-09
Brief Title:
Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis
Sponsor:
University of North Carolina
Organization:
University of North Carolina Chapel Hill
Study Overview
Official Title:
Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis
Status:
COMPLETED
Status Verified Date:
2005-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this research study is to determine whether the combination of inhaled amiloride and a concentrated salt solution is better than the salt solution itself for cystic fibrosis CF patients In CF airway secretions are thick and dehydrated Many patients use inhaled salt solutions to help draw water into their secretions so that they are easier to get rid of with chest physiotherapy chest PT and cough Unfortunately these salt solutions are reabsorbed very quickly by the airways so the beneficial effects may not last very long In the hopes of prolonging their effects the drug amiloride could be used in combination to slow salt and water reabsorption from airways Amiloride is a medication that has been given by mouth for high blood pressure for many years It is possible that the combination of salt solutions and inhaled amiloride may significantly improve the clearance of secretions in CF which would be expected to improve lung function in CF
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None