Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001314
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Investigation of Heart Function in Patients With Heart Valve Defects
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Investigation of Myocardial Contractile Reserve by Dobutamine Stress Transesophageal Echocardiography in Aortic and Mitral Regurgitation
Status:
COMPLETED
Status Verified Date:
2000-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study researchers plan to perform a diagnostic test called transesophageal echocardiography in order to see and record the movement and function of the heart
Transesophageal echocardiography is similar to an upper gastrointestinal endoscopy Different views of the heart are taken by a small flexible instrument positioned in the esophagus the tube that connects the mouth to the stomach This allows doctors to create a clear picture of the heart through the wall of the esophagus rather than from outside the body through the muscles fat and bones of the chest wall
During transesophageal echocardiography pictures of the heart will be taken while patients rest and as patients receive a medication called dobutamine Dobutamine is a medication that makes the heart beat stronger and faster similar to what exercise does to the heart
Researchers are particularly interested in studying patients with defects in the valves of the heart especially aortic regurgitation and mitral regurgitation Patients with these defects in the heart valves tend to develop abnormalities in the size and function of the left ventricle The left ventricle is one of the four chambers of the heart responsible for ejecting blood out of the heart into the circulation Researchers believe that by identifying changes in the function of heart muscle they may be able to predict the occurrence of muscle damage due to the diseased valves
The purpose of this study is to determine whether the function of heart muscle measured during dobutamine stress transesophageal echocardiography can predict the later development of problems in the function and size of the left ventricle
Transesophageal echocardiography is similar to an upper gastrointestinal endoscopy Different views of the heart are taken by a small flexible instrument positioned in the esophagus the tube that connects the mouth to the stomach This allows doctors to create a clear picture of the heart through the wall of the esophagus rather than from outside the body through the muscles fat and bones of the chest wall
During transesophageal echocardiography pictures of the heart will be taken while patients rest and as patients receive a medication called dobutamine Dobutamine is a medication that makes the heart beat stronger and faster similar to what exercise does to the heart
Researchers are particularly interested in studying patients with defects in the valves of the heart especially aortic regurgitation and mitral regurgitation Patients with these defects in the heart valves tend to develop abnormalities in the size and function of the left ventricle The left ventricle is one of the four chambers of the heart responsible for ejecting blood out of the heart into the circulation Researchers believe that by identifying changes in the function of heart muscle they may be able to predict the occurrence of muscle damage due to the diseased valves
The purpose of this study is to determine whether the function of heart muscle measured during dobutamine stress transesophageal echocardiography can predict the later development of problems in the function and size of the left ventricle
Detailed Description:
In this investigation we propose to perform dobutamine stress transesophageal echocardiography in patients with aortic regurgitation and in patients with mitral regurgitation in order to assess myocardial contractile reserve The purpose of the study is to determine whether the contractile reserve of the myocardium measured during dobutamine stress echocardiography is a predictor of the development of subsequent left ventricular dysfunction and left ventricular dilatation as well as recovery of left ventricular function after surgery in these patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 92-H-0195 | None | None | None |