Ignite Creation Date:
2024-05-06 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 12:27 PM
Study NCT ID:
NCT03210493
Status:
UNKNOWN
Last Update Posted:
2017-07-12
First Post:
2017-07-03
Brief Title:
The Changes of Treg Cells Frequency and Function During Antiviral Therapy
Sponsor:
Beijing Ditan Hospital
Organization:
Beijing Ditan Hospital
Study Overview
Official Title:
The Changes of Treg Cells Frequency and Function During Pegylated Interferon α-2a and Nucleoside Analogues Treatment in Patients With Chronic Hepatitis B
Status:
UNKNOWN
Status Verified Date:
2017-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pegylated interferon α-2aPeg-IFN-α not only inhibit viral replication but also play an important role in immune regulation while Nucleoside analogue drugs only inhibit viral replication In hepatitis B infection Treg cells Regulatory T cells played a negative role in immune This study was aimed at investigating the changes of Treg cells frequency and function and the expression of costimulatory molecules during Peg-IFN-αand nucleoside analogue therapyMeanwhile the investigators wanted to verify whether Peg-IFN-α suppressed the virus which led to the decline of Treg cells frequency and functionnegative regulation of Tregs for immune cells diminished hence the function of immune cells recovered
Detailed Description:
Pegylated interferon α-2aPeg-IFN-αand Nucleoside analogue drugs can inhibit viral replication but Peg-IFN-α also play an important role in immune regulation In hepatitis B infection Treg cells play an important role in immune regulationPeg-IFN-α recommended as the first-line treatment has a higher chance to achieve HBeAg seroconversion and even HBsAg disappearance than nucleoside analogue drugs which may be related to the functional activation of Treg cells in the case of hepatitis and the function enhancement of Treg cells during Peg-IFN-α therapy This study was aimed at investigating the changes of Treg cells frequency and function and the expression of costimulatory molecules during Peg-IFN-αand nucleoside analogue therapyMeanwhile the investigators wanted to verify whether Peg-IFN-α suppressed the virus which led to the decline of Treg cells frequency and functionnegative regulation of Tregs for immune cells diminished hence the function of immune cells recovered
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None