Ignite Creation Date:
2025-12-17 @ 3:08 PM
Ignite Modification Date:
2025-12-23 @ 4:52 PM
Study NCT ID:
NCT00734266
Status:
COMPLETED
Last Update Posted:
2013-03-06
First Post:
2008-08-12
Is Possible Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Changes in Leukotrienes During Cardiac Surgery in Patients With Chronic Obstructive Pulmonary Disease
Sponsor:
Massachusetts General Hospital
Organization:
Study Overview
Official Title:
Changes in Leukotrienes During Cardiac Surgery in Patients With Chronic Obstructive Pulmonary Disease
Status:
COMPLETED
Status Verified Date:
2013-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The hypotheses of this study are that:
* Production and release of inflammatory substances called leukotrienes are increased during heart surgery with use of a heart-lung machine in humans;
* The increase in these leukotrienes levels after heart surgery is higher in patients with bronchitis and/or emphysema than in patients without previous history of lung disease;
* Levels of leukotrienes are directly correlated with worsening of lung function during and after heart surgery.
* Production and release of inflammatory substances called leukotrienes are increased during heart surgery with use of a heart-lung machine in humans;
* The increase in these leukotrienes levels after heart surgery is higher in patients with bronchitis and/or emphysema than in patients without previous history of lung disease;
* Levels of leukotrienes are directly correlated with worsening of lung function during and after heart surgery.
Detailed Description:
In this project, we will test the hypothesis that cys-leukotrienes are released and correlated with the impairment of the lung function after cardiac surgery in patients with COPD. If such hypothesis is substantiated in the study, it would allow us to propose the use of leukotriene inhibitors in the peri-operative period to improve pulmonary function and to decrease complications after cardiac surgery in COPD patients.
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: