Ignite Creation Date:
2024-05-05 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00272233
Status:
COMPLETED
Last Update Posted:
2007-03-20
First Post:
2006-01-03
Brief Title:
Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents
Sponsor:
Yale University
Organization:
Yale University
Study Overview
Official Title:
Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents
Status:
COMPLETED
Status Verified Date:
2006-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Work requirements for medical trainees result in substantial sleep loss Sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood vessel function The purpose of this study is to determine the effects of sleep loss on blood hormone levels and blood vessel function in medical trainees
Detailed Description:
Context Sleep loss is associated with increased blood levels of interleukin-6 IL-6 and C-reactive protein CRP Medical residents are often deprived of normal sleep during extended work shifts but the effects of work-related sleep loss on biomarkers of vascular inflammation and function are unknown
Objective We sought to test the hypothesis that sleep loss during extended work shifts during medical training is associated with increased circulating levels of pro-inflammatory biomarkers and evidence of vascular dysfunction
Design Outcome measures were assessed after extended 30-hour work shifts and non-extended 6-hour work shifts in a single-blind randomized crossover design
Setting University hospital medical intensive care unit
Patients or Other Participants Twenty-two healthy medical residents were studied during a medical intensive care unit rotation
Main Outcome Measures Sleep related cytokines interleukin-6 and tumor necrosis factor serum markers of vascular inflammation C-reactive protein and flow-mediated dilation in the brachial artery
Objective We sought to test the hypothesis that sleep loss during extended work shifts during medical training is associated with increased circulating levels of pro-inflammatory biomarkers and evidence of vascular dysfunction
Design Outcome measures were assessed after extended 30-hour work shifts and non-extended 6-hour work shifts in a single-blind randomized crossover design
Setting University hospital medical intensive care unit
Patients or Other Participants Twenty-two healthy medical residents were studied during a medical intensive care unit rotation
Main Outcome Measures Sleep related cytokines interleukin-6 and tumor necrosis factor serum markers of vascular inflammation C-reactive protein and flow-mediated dilation in the brachial artery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIH NHLBI K24 04024 | None | None | None |