Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001528
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Post-Stress Left Ventricular Contractile Dysfunction Does It Represent Persistent Myocardial Ischemia or Stunning
Status:
COMPLETED
Status Verified Date:
2000-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to examine the blood flow the nutrition and the beating function of the heart under different conditions Patients with narrowed coronary arteries my have restricted blood flow to the heart The lowered blood supply to the heart muscle may not cause symptoms immediately However as the heart pumps faster and harder the blood supply demand is increased If blood flow is unable supply enough oxygen and nutrition to heart muscle patients can experience symptoms of chest pain and shortness of breath Even after the heart slows down and demand for oxygen and nutrition is reduced patients can still experience pain and abnormal heart function
The purpose of this study is to determine the changes in blood flow and the beating function of the heart during periods of increased demands such as exercise and shortly after stopping exercise
Blood flow to the heart will be measured by positron emission tomography PET scan The PET scan is a test where a small amount of radioactive water is injected into the bloodstream and pictures of the heart are taken by the special camera This procedure allows researchers to measure blood flow to heart muscle In order to measure nutrition metabolism of the heart muscle researchers will use a radioactive substance similar to sugar Fluorodeoxyglucose
Results of this study may provide important information about the activity and function of heart muscle after exercise in patients suffering from coronary artery disease
The purpose of this study is to determine the changes in blood flow and the beating function of the heart during periods of increased demands such as exercise and shortly after stopping exercise
Blood flow to the heart will be measured by positron emission tomography PET scan The PET scan is a test where a small amount of radioactive water is injected into the bloodstream and pictures of the heart are taken by the special camera This procedure allows researchers to measure blood flow to heart muscle In order to measure nutrition metabolism of the heart muscle researchers will use a radioactive substance similar to sugar Fluorodeoxyglucose
Results of this study may provide important information about the activity and function of heart muscle after exercise in patients suffering from coronary artery disease
Detailed Description:
Exercise-induced left ventricular regional wall motion abnormalities among patients with coronary artery disease indicate myocardial ischemia due to significant coronary artery narrowing Recovery of such stress-induced wall motion abnormalities is thought to occur within minutes after the termination of exercise However in some patients persistent contractile dysfunction has been observed up to 90 minutes into recovery Whether persistent regional wall motion abnormalities after exercise are due to stunned myocardium prolonged but reversible postischemic dysfunction despite restoration of blood flow or persistent ischemia due to coronary vasoconstriction prolonged postischemic dysfunction due to persistent reduction of regional blood flow is not well established It is possible that persistent but reversible left ventricular dysfunction post-exercise may represent persistent reduction in regional blood flow andor altered regional metabolic state
In this protocol we intend to elucidate the mechanisms of prolonged but reversible post-exercise left ventricular contractile dysfunction Results of this study may provide insight into the post-exercise cardiovascular physiology among patients with coronary artery disease In addition clinical implications can be drawn regarding patient safety and timing of discharge from the exercise laboratory as well as timing of post-exercise myocardial perfusion studies
We propose to evaluate left ventricular regional wall motion by gated blood pool tomographic SPECT imaging at rest during maximal exercise 15 and 30 minutes after termination of exercise Myocardial perfusion O-15 water and metabolic F-18 deoxyglucose studies will be performed utilizing positron emission tomography PET Absolute regional myocardial blood flow mlmingm will be assessed at rest during maximal exercise 15 and 30 minutes post-exercise along with myocardial fluorodeoxyglucose utilization 45 to 90 minutes post-exercise Patients afflicted with conditions that limit their capacity to perform an adequate exercise study will undergo pharmacological stress study with dobutamine Normal subjects will also be studied in order to create a control database
In this protocol we intend to elucidate the mechanisms of prolonged but reversible post-exercise left ventricular contractile dysfunction Results of this study may provide insight into the post-exercise cardiovascular physiology among patients with coronary artery disease In addition clinical implications can be drawn regarding patient safety and timing of discharge from the exercise laboratory as well as timing of post-exercise myocardial perfusion studies
We propose to evaluate left ventricular regional wall motion by gated blood pool tomographic SPECT imaging at rest during maximal exercise 15 and 30 minutes after termination of exercise Myocardial perfusion O-15 water and metabolic F-18 deoxyglucose studies will be performed utilizing positron emission tomography PET Absolute regional myocardial blood flow mlmingm will be assessed at rest during maximal exercise 15 and 30 minutes post-exercise along with myocardial fluorodeoxyglucose utilization 45 to 90 minutes post-exercise Patients afflicted with conditions that limit their capacity to perform an adequate exercise study will undergo pharmacological stress study with dobutamine Normal subjects will also be studied in order to create a control database
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 96-H-0031 | None | None | None |