Ignite Creation Date:
2024-05-05 @ 4:36 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00273650
Status:
COMPLETED
Last Update Posted:
2019-10-09
First Post:
2006-01-06
Brief Title:
Efficacy Study of Subcutaneous Methyl-B12 in Children With Autism
Sponsor:
University of California San Francisco
Organization:
University of California San Francisco
Study Overview
Official Title:
Double-Blind Placebo Controlled Cross-over Trial of Subcutaneous B12 on Behavioral and Metabolic Measures in Children With Autism
Status:
COMPLETED
Status Verified Date:
2019-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We will be testing a specific dietary supplement methylcobalamin vitamin B12 Follow-up assessments with our clinical team will take place over the 12-week study period so that we can record any changes in development The main goal of this study is to determine if subcutaneous injections of vitamin B12 given every three days can positively affect behavior and development in children with autism
Hypothesis Methylcobalamin injections will improve measures of executive function speech and socialization in children with autism and will be associated with metabolic improvement
Hypothesis Methylcobalamin injections will improve measures of executive function speech and socialization in children with autism and will be associated with metabolic improvement
Detailed Description:
Autism is a complex neurodevelopmental disorder that is thought to involve an interaction between multiple and variable susceptibility genes Keller Persico 2003 epigenetic effects Beaudet 2002 and environmental factors London 2000 The increase in the prevalence of autistic spectrum disorders from 4-510000 in the 1980s to 30-6010000 in the last decade has raised great concern Bertrand et al 2001 DeStefano et al 2004 Steinhausen et al 1986 Yeargin-Allsopp et al 2003 Research into potential therapeutic interventions designed to ameliorate the metabolic and clinical symptoms of autism is urgently needed to reduce the enormous public health burden of this disorder and to improve the quality of life for affected children and their families Nutritional supplementation through subcutaneous injections of methyl B12 is a current treatment for children with autism that has anecdotal reports of remarkable clinical improvements and few side effects However there are no published studies to support its clinical benefit
Comparison Injections of methylcobalamin compared to injections of sterile saline over a six week period
Comparison Injections of methylcobalamin compared to injections of sterile saline over a six week period
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None