Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005300
Status:
COMPLETED
Last Update Posted:
2016-04-14
First Post:
2000-05-25
Brief Title:
Investigation of Selected Patient Groups From The Cooperative Study of Sickle Cell Disease
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To continue to follow the newborn cohort and the over-35 years of age cohort from the Cooperative Study of Sickle Cell Disease CSSCD a study of the natural history of sickle cell disease
Detailed Description:
BACKGROUND
The Cooperative Study of Sickle Cell Disease was initiated in 1977 to determine the natural history of sickle cell disease from birth to death in order to identify those factors contributing to the morbidity and mortality of the disease Patients in the study had been followed previously in CSSCD
Follow-up of the newborn cohort provided data demonstrating that life-threatening septicemia can occur as early as four months of age and that the incidence of septicemia in children with sickle cell disease is higher than previously reported Serial measurements of pocked or vesiculated red blood cells determined the onset of splenic dysfunction The loss of splenic function has been characterized by genotype and the observed patterns of loss of splenic function were different developmentally depending on the sickle hemoglobinopathy syndrome
Growth retardation which becomes obvious around seven years of age has no relationship to reported family income Prophylactic oral penicillin can decrease morbidity and mortality associate with pneumococcal septicemia The newborn infant cohort was unique in determining issues related to the natural history of the disease because the information was prospective and has been captured in the database The complex database permitted an opportunity to determine outcomes risk factors and the application of the severity index to determine the spectrum of severity
Follow-up of the over-35 cohort is important because it was not so long ago that it was estimated that 50 percent of patients with sickle cell anemia in the United States died before their twentieth birthday However data accumulated over the past eight years by the CSSCD demonstrates that this is incorrect Survival beyond the age of forty suggests that surviving patients are somehow different from other patients with a high mortality in the earlier years Therefore they constitute a cohort of special interest and the reasons for prolonged survival in this disease remain to be well documented prospectively Technology is now available to identify genetic differences which may influence survival
Based on the findings of the earlier CSSCD the Blood Diseases and Resources Advisory Committee Red Cell Working Group recommended this initiative which was approved by the May 1987 National Heart Lung and Blood Advisory Council The Request for Proposals was released in February 1988 and awards made in October 1988
DESIGN NARRATIVE
Follow-up of the newborn cohort continued in order to better understand the severity onset of early organ damage and risk factors Patients were given an entry evaluation consisting of interim history complete physical examination complete blood count urinalysis blood drawn for haplotype determination and for the serum bank magnetic resonance imaging of the brain pulmonary function tests with arterial blood gas and psychomotor tests Patients had interim assessments at six months and annual assessments as well as an exit assessment in the fourth or fifth years The exit assessment was the same as the entry assessment
Follow-up of the over-35 cohort continued in order to better understand factors that contribute to longevity Entry evaluation consisted of interim history complete physical examination complete blood count urinalysis blood drawn for haplotype determination and for the serum bank cardiac MUGA and renal and pulmonary function tests Follow-up was yearly with an exit evaluation in the fourth or fifth years
The Cooperative Study of Sickle Cell Disease was initiated in 1977 to determine the natural history of sickle cell disease from birth to death in order to identify those factors contributing to the morbidity and mortality of the disease Patients in the study had been followed previously in CSSCD
Follow-up of the newborn cohort provided data demonstrating that life-threatening septicemia can occur as early as four months of age and that the incidence of septicemia in children with sickle cell disease is higher than previously reported Serial measurements of pocked or vesiculated red blood cells determined the onset of splenic dysfunction The loss of splenic function has been characterized by genotype and the observed patterns of loss of splenic function were different developmentally depending on the sickle hemoglobinopathy syndrome
Growth retardation which becomes obvious around seven years of age has no relationship to reported family income Prophylactic oral penicillin can decrease morbidity and mortality associate with pneumococcal septicemia The newborn infant cohort was unique in determining issues related to the natural history of the disease because the information was prospective and has been captured in the database The complex database permitted an opportunity to determine outcomes risk factors and the application of the severity index to determine the spectrum of severity
Follow-up of the over-35 cohort is important because it was not so long ago that it was estimated that 50 percent of patients with sickle cell anemia in the United States died before their twentieth birthday However data accumulated over the past eight years by the CSSCD demonstrates that this is incorrect Survival beyond the age of forty suggests that surviving patients are somehow different from other patients with a high mortality in the earlier years Therefore they constitute a cohort of special interest and the reasons for prolonged survival in this disease remain to be well documented prospectively Technology is now available to identify genetic differences which may influence survival
Based on the findings of the earlier CSSCD the Blood Diseases and Resources Advisory Committee Red Cell Working Group recommended this initiative which was approved by the May 1987 National Heart Lung and Blood Advisory Council The Request for Proposals was released in February 1988 and awards made in October 1988
DESIGN NARRATIVE
Follow-up of the newborn cohort continued in order to better understand the severity onset of early organ damage and risk factors Patients were given an entry evaluation consisting of interim history complete physical examination complete blood count urinalysis blood drawn for haplotype determination and for the serum bank magnetic resonance imaging of the brain pulmonary function tests with arterial blood gas and psychomotor tests Patients had interim assessments at six months and annual assessments as well as an exit assessment in the fourth or fifth years The exit assessment was the same as the entry assessment
Follow-up of the over-35 cohort continued in order to better understand factors that contribute to longevity Entry evaluation consisted of interim history complete physical examination complete blood count urinalysis blood drawn for haplotype determination and for the serum bank cardiac MUGA and renal and pulmonary function tests Follow-up was yearly with an exit evaluation in the fourth or fifth years
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: