Ignite Creation Date:
2024-05-05 @ 4:38 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00284453
Status:
COMPLETED
Last Update Posted:
2019-02-12
First Post:
2006-01-27
Brief Title:
Ventricular Tachyarrhythmia VT Storm Gene Expression in Implantable Cardioverter Defibrillator ICD Patients With Electrical Storm
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Gene Expression in ICD Patients With Electrical Storm
Status:
COMPLETED
Status Verified Date:
2019-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the proposed pilot study is to identify factors which are associated with periods of high ventricular arrhythmia burden This will be performed by analysis of gene expression from peripheral blood samples
Detailed Description:
This is a study of patients with ICD implants who present with multiple2 low-level1-2 or inappropriate therapies to their defibrillator The purpose of this pilot study is to identify factors which are associated with periods of high ventricular arrhythmia burden by looking at gene expression from peripheral blood in addition to levels of known markers of CHF including catecholamine levels B-type natriuretic peptide and troponin This study hypothesizes that extrinsic or systemic factors play a role in triggering these events and if true should yield candidate proteins which would spawn functional studies to prove a role in causation Additionally identification of a marker of increased recurrence of events may aid in guiding therapy starting an anti-arrhythmic versus awaiting the next event
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None