Ignite Creation Date:
2024-05-05 @ 4:38 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00287443
Status:
WITHDRAWN
Last Update Posted:
2018-12-26
First Post:
2006-02-02
Brief Title:
Metabolic Abnormalities in Hispanic Children With Cystic Fibrosis
Sponsor:
University of Texas Southwestern Medical Center
Organization:
University of Texas Southwestern Medical Center
Study Overview
Official Title:
None
Status:
WITHDRAWN
Status Verified Date:
2018-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
PI no longer with the University
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Our specific aims include
1 AIM 1 Characterization of glucose tolerance nutritional and clinical status socioeconomic status family history of diabetes and genotype in Hispanic CF children compared to Caucasian CF children Each child will undergo a two-hour oral glucose tolerance test and will be categorized by glucose tolerance according to standards set forth by the 1998 CF Consensus Conference on Diabetes Nutritional status will be determined by three-day food journals and intake will be compared to energy needs measured by indirect calorimetry Socio-economic status will be calculated from reported family income and medical insurance coverage Genotyping will be done at the laboratory of Dr Arthur Beaudet at Baylor College of Medicine Clinical status will be measured using modified NIH scores Family history for both type 1 and type 2 diabetes will be obtained in Spanish by DrVanderwel This specific aim tests the hypothesis that glucose intolerance frank CF related diabetes occurs at a younger age in Hispanics than in Caucasians with CF and is correlated to family history of diabetes and clinical status
2 AIM 2 Characterization of insulin secretion and insulin sensitivity Previous studies in adults have described peripheral insulin resistance as a major cause of CF related diabetes yet studies have not been conducted in children Studies in adults and children without CF suggest that insulin resistance occurs more frequently in Hispanics We will measure insulin secretion and insulin sensitivity using the frequently sampled intravenous glucose tolerance test IVGTT and the minimal model analysis of Bergman as modified for children This specific aim tests the hypothesis that Hispanic children with CF have worse peripheral insulin resistance but similar insulin secretion when compared to Caucasian children with CF
3 AIM 3 Quantification of post-absorptive gluconeogenesis and whole body protein turnover Total hepatic glucose production HGP will be measured using 66-2H2glucose We will quantify gluconeogenesis by measurement of the incorporation of 2H into the 2nd 5th and 6th carbons of glucose following 2H20 administration method of Landau We will determine whole body protein turnover using the stable isotopes 1-13Cleucine and will measure serum amino acid levels This specific aim tests the hypothesis that gluconeogenesis and whole body protein turnover are disproportionately higher in Hispanic children and adolescents with CF than in Caucasian CF children
1 AIM 1 Characterization of glucose tolerance nutritional and clinical status socioeconomic status family history of diabetes and genotype in Hispanic CF children compared to Caucasian CF children Each child will undergo a two-hour oral glucose tolerance test and will be categorized by glucose tolerance according to standards set forth by the 1998 CF Consensus Conference on Diabetes Nutritional status will be determined by three-day food journals and intake will be compared to energy needs measured by indirect calorimetry Socio-economic status will be calculated from reported family income and medical insurance coverage Genotyping will be done at the laboratory of Dr Arthur Beaudet at Baylor College of Medicine Clinical status will be measured using modified NIH scores Family history for both type 1 and type 2 diabetes will be obtained in Spanish by DrVanderwel This specific aim tests the hypothesis that glucose intolerance frank CF related diabetes occurs at a younger age in Hispanics than in Caucasians with CF and is correlated to family history of diabetes and clinical status
2 AIM 2 Characterization of insulin secretion and insulin sensitivity Previous studies in adults have described peripheral insulin resistance as a major cause of CF related diabetes yet studies have not been conducted in children Studies in adults and children without CF suggest that insulin resistance occurs more frequently in Hispanics We will measure insulin secretion and insulin sensitivity using the frequently sampled intravenous glucose tolerance test IVGTT and the minimal model analysis of Bergman as modified for children This specific aim tests the hypothesis that Hispanic children with CF have worse peripheral insulin resistance but similar insulin secretion when compared to Caucasian children with CF
3 AIM 3 Quantification of post-absorptive gluconeogenesis and whole body protein turnover Total hepatic glucose production HGP will be measured using 66-2H2glucose We will quantify gluconeogenesis by measurement of the incorporation of 2H into the 2nd 5th and 6th carbons of glucose following 2H20 administration method of Landau We will determine whole body protein turnover using the stable isotopes 1-13Cleucine and will measure serum amino acid levels This specific aim tests the hypothesis that gluconeogenesis and whole body protein turnover are disproportionately higher in Hispanic children and adolescents with CF than in Caucasian CF children
Detailed Description:
We will recruit 12 Hispanic prepubertal children with CF ages 7-12 Tanner I and 12 Hispanic adolescents ages 15-17 Tanner 3 or 4 from the CF Centers at University of Texas Southwestern and Baylor College of Medicine in Houston Information obtained from these subjects will be compared to 12 prepubertal and 12 adolescent Caucasian children with CF recruited from the same CF centers We will categorize the subjects according to glucose tolerance OGTT as well as insulin secretion and insulin sensitivity using the IVGTT and the Minimal Model as modified for children We will also compare the historical information of socio-economic status and family history Clinical status will be characterized by measuring pulmonary function and modified NIH scores in addition to measuring levels of circulating cytokines Gluconeogenesis GNG will be quantified by measuring the incorporation 2H into the 2nd 5th and 6th carbons of glucose Whole body protein turnover WBPT will be measured using 1-13Cleucine Nutritional status will be determined by three-day food journals and intake will be compared to energy needs utilizing indirect calorimetry to measure resting energy expenditure Subjects will be recruited from the CF centers at the University of Texas- Southwestern and the South Central CF Consortium
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None