Ignite Creation Date:
2024-05-06 @ 10:40 AM
Last Modification Date:
2024-10-26 @ 12:34 PM
Study NCT ID:
NCT03324945
Status:
COMPLETED
Last Update Posted:
2020-11-12
First Post:
2017-09-15
Brief Title:
Chemotherapy-Induced Cognitive Impairment in Ovarian Cancer Patients
Sponsor:
Rachel Miller
Organization:
University of Kentucky
Study Overview
Official Title:
Chemotherapy-Induced Cognitive Impairment in Patients With Ovarian Cancer A Phase II Study of the Cognitive Effects of PlatinumTaxane-based Chemotherapy in Patients With Ovarian Cancer
Status:
COMPLETED
Status Verified Date:
2020-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chemotherapy-induced cognitive impairment CICI also known as chemobrain is a spectrum of neurocognitive deficits experienced during and after the administration of chemotherapy for cancer The incidence of CICI is significant affecting anywhere from 25 to 75 of survivors and the biologic basis is unknown This novel study is designed to address the questions of incidence and biological cause for CICI while gaining a better understanding of the structural and functional effects of chemotherapy on the brain
Detailed Description:
Chemotherapy-induced cognitive impairment CICI also known as chemobrain is a spectrum of neurocognitive deficits experienced during and after the administration of chemotherapy for cancer The incidence of CICI is significant affecting anywhere from 25 to 75 of survivors and the biologic basis is unknown This novel study is designed to address the questions of incidence and biological cause for CICI while gaining a better understanding of the structural and functional effects of chemotherapy on the brain In order to address these important objectives a diverse team of experienced investigators has been assembled to design and implement the proposed protocol The research team for this project seeks to accomplish the proposed objectives through following mechanisms 1 assessment of the neurocognitive domains affected in CICI using a tailored battery of cognitive tests to define CICI 2 measurement of serum markers of oxidative stress and correlation of these markers with neurocognitive test results and 3 exploration of structural and functional changes in the brain during cognitive tasks and correlation of results with markers of oxidative stress and neurocognitive test results
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None