Ignite Creation Date:
2025-12-24 @ 4:27 PM
Ignite Modification Date:
2025-12-24 @ 4:27 PM
Study NCT ID:
NCT05752266
Status:
COMPLETED
Last Update Posted:
2024-11-29
First Post:
2023-02-17
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Effect of Probiotics on Amino Acid Absorption
Sponsor:
Singapore Institute of Technology
Organization:
Study Overview
Official Title:
Effect of Probiotics on Amino Acid Absorption
Status:
COMPLETED
Status Verified Date:
2024-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to test effects of consuming probiotics in healthy adults. The main question it aims to answer is:
• Do consuming probiotics affect a healthy adult's ability to absorb amino acids from plant proteins?
Participants will
* Consume one dose of probiotic pills per day after meals for two weeks
* Consume one dose of plant-based plant protein beverage after an overnight fast and collection of one 5 ml fasting blood sample
* Undergo blood draw of 6 more 5 ml blood samples for the next 3 hours after consuming plant-based protein beverage
• Do consuming probiotics affect a healthy adult's ability to absorb amino acids from plant proteins?
Participants will
* Consume one dose of probiotic pills per day after meals for two weeks
* Consume one dose of plant-based plant protein beverage after an overnight fast and collection of one 5 ml fasting blood sample
* Undergo blood draw of 6 more 5 ml blood samples for the next 3 hours after consuming plant-based protein beverage
Detailed Description:
There is increasing evidence that the gut microbiota contributes to a range of immune, inflammatory, and metabolic responses. Numerous studies have shown that administrating probiotics - strains of bacteria that benefits intestinal function - confer benefits to the host's immune system. Except for soy protein, plant proteins are incomplete proteins lacking in one or more essential amino acids. The incomplete amino acid profile of most plant proteins is compounded by their lower rate of absorption as compared to animal protein. Hence, the investigators aim to investigate the administration of probiotics as a potential strategy to overcome compositional shortcomings of plant proteins by improving the gastrointestinal absorption of plant-based proteins.
The aim of Stage 1 is to formulate a plant-based protein beverage with optimized amino acid profile with consumer acceptance.
Stage 2 of this study will be to conduct a randomized, double-blind, placebo-controlled, crossover trial using the formulation developed in Stage 1, together with probiotics supplementation to evaluate the effect of probiotics on the absorption of amino acids from plant proteins.
The probiotics to be studied will be provided by the Asian Microbiome Library (AMILI) with the plant protein beverage to be developed within SIT. Findings from this mutually beneficial collaborative project with AMILI will pave the way to further understand the role of probiotics in human health, particularly its effect in nutrient absorption of plant protein.
The aim of Stage 1 is to formulate a plant-based protein beverage with optimized amino acid profile with consumer acceptance.
Stage 2 of this study will be to conduct a randomized, double-blind, placebo-controlled, crossover trial using the formulation developed in Stage 1, together with probiotics supplementation to evaluate the effect of probiotics on the absorption of amino acids from plant proteins.
The probiotics to be studied will be provided by the Asian Microbiome Library (AMILI) with the plant protein beverage to be developed within SIT. Findings from this mutually beneficial collaborative project with AMILI will pave the way to further understand the role of probiotics in human health, particularly its effect in nutrient absorption of plant protein.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: