Ignite Creation Date:
2024-05-05 @ 4:39 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00281086
Status:
COMPLETED
Last Update Posted:
2016-07-29
First Post:
2006-01-20
Brief Title:
Center for Reducing Asthma Disparities - Harvard UniversityBoston Area Community Health Centers
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To address the problems of disparities in asthma care and morbidity by examining the influence of environmentalgenetic factors and stress on the development of asthma
Detailed Description:
BACKGROUND
Asthma is a serious chronic condition affecting over 14 million Americans but the prevalence rates are higher in certain populations eg 10 percent in inner-cities and 30 percent among the homeless vs 5 percent in a general population of whites African Americans and Hispanics from the Northeast are twice as likely to die from asthma as whites African Americans are four times as likely to be hospitalized for asthma and are five times more likely than whites to seek care for asthma at an emergency department Reasons for these higher rates are not certain and most likely result from an interaction of risk factors such as environmental exposures genetic predisposition access to appropriate medical care socioeconomic status and cultural health practices The National Heart Lung and Blood Institute supports a variety of activities to address the pressing public health problems posed by asthma However progress in reducing disparities has been disappointingly slow Separate independent research projects have generated important clues for understanding the nature and scope of the problem A more coordinated interdisciplinary and comprehensive approach to research is needed to take advantage of these clues move the science further and faster and increase our capacity to improve health outcomes among minority and economically disadvantaged populations Cooperative centers of research that foster partnerships among minority medical centers research intensive institutions and the communities in which asthma patients live will promote such advancement
The Request for Applications for the Centers for Reducing Asthma Disparities was released in October 2001 The objective of the program is to promote partnerships called Centers between a minority serving institution MSI that may not have a strong research program and a research intensive institution RII that has a track record of NIH-supported research and patient care The purpose of the partnership is to conduct collaborative research on asthma disparities ie greater prevalence of asthma higher rates of morbidity due to asthma and lesser access or use of quality medical care among minorities and poor
DESIGN NARRATIVE
The Center for Reducing Asthma Disparities involves partnership between researchers at Harvard University Channing Laboratory Brigham and Womens Hospital and the Harvard School of Public Health and a network of Boston-area Community Health Centers CHCs affiliated with the non-profit community-based organization CCHERS Center for Community Health Education Research and Service Broad specific aims are 1 Conduct a community needs assessment to assess differences in perceptions about asthma etiology disparities and effective treatment between community representatives Community Health Center patients and Community Health Center providers 2 Determine the role of socioenvironmental exposures psychosocial stress indoor allergens cigarette smoking and diesel-related air pollutants on asthma onset through study of a prenatally enrolled birth cohort 3 Determine the role of genetics in modifying the risk of the socialphysical environment by concurrent assessment of the following genetic factors thought to influence immune development and airway inflammation in early life stress corticosteroid regulatory genes adrenergic system regulatory genes diesel exhaust and smoking biotransformation genes indoor allergens cytokine pathway genes 4 Use a quasi-experimental design to evaluate the effectiveness of the research training and outreach components of the project in leading to significant changes in the ability of particular stakeholders to design and implement sound asthma intervention strategies 5 Develop training programs at Harvard that provide masters and predoctoral students as well as postdoctoral fellows with experience and expertise in Community-Based Participatory Research CBPR focused on reducing asthma disparities 6 Develop training and information dissemination materials for health center staff and community members especially caregivers of children with asthma The Center for Community Health Education Research and Service will take the lead in implementing Specific Aims 1 4 and 6 while the Harvard group will take the lead on Aims 2 3 and 5 In addition to building needed infrastructure to support partnership-based research and interventions aimed at reducing health disparities this proposal has the potential to make significant contributions to the scientific literature with respect to health disparities and asthma
Asthma is a serious chronic condition affecting over 14 million Americans but the prevalence rates are higher in certain populations eg 10 percent in inner-cities and 30 percent among the homeless vs 5 percent in a general population of whites African Americans and Hispanics from the Northeast are twice as likely to die from asthma as whites African Americans are four times as likely to be hospitalized for asthma and are five times more likely than whites to seek care for asthma at an emergency department Reasons for these higher rates are not certain and most likely result from an interaction of risk factors such as environmental exposures genetic predisposition access to appropriate medical care socioeconomic status and cultural health practices The National Heart Lung and Blood Institute supports a variety of activities to address the pressing public health problems posed by asthma However progress in reducing disparities has been disappointingly slow Separate independent research projects have generated important clues for understanding the nature and scope of the problem A more coordinated interdisciplinary and comprehensive approach to research is needed to take advantage of these clues move the science further and faster and increase our capacity to improve health outcomes among minority and economically disadvantaged populations Cooperative centers of research that foster partnerships among minority medical centers research intensive institutions and the communities in which asthma patients live will promote such advancement
The Request for Applications for the Centers for Reducing Asthma Disparities was released in October 2001 The objective of the program is to promote partnerships called Centers between a minority serving institution MSI that may not have a strong research program and a research intensive institution RII that has a track record of NIH-supported research and patient care The purpose of the partnership is to conduct collaborative research on asthma disparities ie greater prevalence of asthma higher rates of morbidity due to asthma and lesser access or use of quality medical care among minorities and poor
DESIGN NARRATIVE
The Center for Reducing Asthma Disparities involves partnership between researchers at Harvard University Channing Laboratory Brigham and Womens Hospital and the Harvard School of Public Health and a network of Boston-area Community Health Centers CHCs affiliated with the non-profit community-based organization CCHERS Center for Community Health Education Research and Service Broad specific aims are 1 Conduct a community needs assessment to assess differences in perceptions about asthma etiology disparities and effective treatment between community representatives Community Health Center patients and Community Health Center providers 2 Determine the role of socioenvironmental exposures psychosocial stress indoor allergens cigarette smoking and diesel-related air pollutants on asthma onset through study of a prenatally enrolled birth cohort 3 Determine the role of genetics in modifying the risk of the socialphysical environment by concurrent assessment of the following genetic factors thought to influence immune development and airway inflammation in early life stress corticosteroid regulatory genes adrenergic system regulatory genes diesel exhaust and smoking biotransformation genes indoor allergens cytokine pathway genes 4 Use a quasi-experimental design to evaluate the effectiveness of the research training and outreach components of the project in leading to significant changes in the ability of particular stakeholders to design and implement sound asthma intervention strategies 5 Develop training programs at Harvard that provide masters and predoctoral students as well as postdoctoral fellows with experience and expertise in Community-Based Participatory Research CBPR focused on reducing asthma disparities 6 Develop training and information dissemination materials for health center staff and community members especially caregivers of children with asthma The Center for Community Health Education Research and Service will take the lead in implementing Specific Aims 1 4 and 6 while the Harvard group will take the lead on Aims 2 3 and 5 In addition to building needed infrastructure to support partnership-based research and interventions aimed at reducing health disparities this proposal has the potential to make significant contributions to the scientific literature with respect to health disparities and asthma
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U01HL072495 | NIH | None | httpsreporternihgovquickSearchU01HL072495 |