Ignite Creation Date:
2024-05-06 @ 10:52 AM
Last Modification Date:
2024-10-26 @ 12:36 PM
Study NCT ID:
NCT03370627
Status:
COMPLETED
Last Update Posted:
2020-08-27
First Post:
2017-12-07
Brief Title:
Effect of Anti-CD303 Antibodies in Autoimmune Diseases
Sponsor:
University Hospital Lille
Organization:
University Hospital Lille
Study Overview
Official Title:
Effect of Monoclonal Anti-cd303 on the Inhibition of Type I Interferon Secretion in the Peripheral Blood of Patients With Autoimmune Diseases
Status:
COMPLETED
Status Verified Date:
2020-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ANTI-CD303
Brief Summary:
The pathogenic role of type I interferons IFNs in the development of different autoimmune diseases has been extensively described in the literature Since plasmacytoid dendritic cells pDCs are the main source of type I IFNs there is evidence of the involvement of pDCs in autoimmune diseases The CD303 surface protein also called BDCA-2 is specifically expressed by the pDCs
The hypothesis leading to the realization of this study is to observe in vitro an inhibition of the secretion of the type I IFNs by pDCs in the peripheral blood in patients with autoimmune disease thanks to the action of the anti-CD303 antibody Developed by the LFB Group which could reduce the inflammatory response and improve patients with autoimmune disease
The hypothesis leading to the realization of this study is to observe in vitro an inhibition of the secretion of the type I IFNs by pDCs in the peripheral blood in patients with autoimmune disease thanks to the action of the anti-CD303 antibody Developed by the LFB Group which could reduce the inflammatory response and improve patients with autoimmune disease
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2017_A02244-49 | OTHER | ID-RCB number ANSM | None |