Ignite Creation Date:
2024-05-05 @ 4:39 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00280501
Status:
COMPLETED
Last Update Posted:
2008-07-09
First Post:
2006-01-19
Brief Title:
Dopaminergic Modulation of Choroidal Blood Flow Changes During DarkLight Transitions
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Dopaminergic Modulation of Choroidal Blood Flow Changes During DarkLight Transitions
Status:
COMPLETED
Status Verified Date:
2008-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
There is evidence from a variety of animal studies that choroidal blood flow is under neural control By contrast only little information is available from human studies Recent results indicate that a lightdark transition is associated with a reduction in choroidal blood flow due to an unknown mechanism We have shown that during unilateral darklight transitions both eyes react with choroidal vasoconstriction strongly indicating a neural mechanism responsible for the blood flow changes
Dopamine has been discussed as a chemical messenger for light adaptation However dopaminergic effects in the eye are not restricted to synaptic sites of release but dopamine also diffuses to the outer retinal layers and pigment epithelium Accordingly dopaminergic effects also include a modulatory role on retinal vessel diameter and animal studies provide evidence for vasodilatory effects in the choroid There is evidence that during darkness retinal and choroidal dopamine levels decrease Accordingly dopamine could provide a modulatory input to the lightdark transition induced changes of choroidal circulation The aim of the present study is to test this hypothesis
Dopamine has been discussed as a chemical messenger for light adaptation However dopaminergic effects in the eye are not restricted to synaptic sites of release but dopamine also diffuses to the outer retinal layers and pigment epithelium Accordingly dopaminergic effects also include a modulatory role on retinal vessel diameter and animal studies provide evidence for vasodilatory effects in the choroid There is evidence that during darkness retinal and choroidal dopamine levels decrease Accordingly dopamine could provide a modulatory input to the lightdark transition induced changes of choroidal circulation The aim of the present study is to test this hypothesis
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None