Ignite Creation Date:
2024-05-05 @ 4:41 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00292201
Status:
TERMINATED
Last Update Posted:
2015-09-16
First Post:
2006-02-14
Brief Title:
Statin Treatment in Patients With Asthma
Sponsor:
Queens University
Organization:
Queens University
Study Overview
Official Title:
Pilot Study of Statin Treatment in Patients With Stable Moderate to Severe Asthma
Status:
TERMINATED
Status Verified Date:
2015-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Lack of funding to complete subject recruitment and testing
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Asthma is a chronic respiratory condition characterized by bronchial hyper-responsiveness secondary to abnormal inflammation of the lung Steroids remain the most effective treatment for this condition The lipid lowering agents statins have been found to have anti-inflammatory properties This study is to test the hypothesize that statins will decrease bronchial hyperresponsiveness and inflammation leading to improved symptoms in patients with asthma
Detailed Description:
Asthma affects 7 - 12 of the population in North America and results in substantial morbidity and health care costs Management of asthma is focused towards reducing airway inflammation through a combination of avoidance of inciting and triggering pro-inflammatory agents as well as anti-inflammatory medication Corticosteroids and anti-leukotrienes are efficacious but are neither universally effective nor free of side effects Statins which are currently widely prescribed and used safely to improve serum lipids and cholesterol have anti-inflammatory properties which may be clinically useful in asthma either in addition to or perhaps instead of corticosteroids
The objective of this research proposal is to conduct a randomized placebo controlled trial of 4 weeks statin therapy in patients in moderate to severe but stable asthma We hypothesize that statins may directly reduce airway inflammation andor contribute to the anti-inflammatory effects of corticosteroid treatment in these patients We will measure the effects of statins by measuring airway sensitivity to methacholine pulmonary function sputum eosinophils and quality of life in subjects with asthma after 4 weeks of treatment Statins may become an alternative treatment option or act as steroid sparing agents in patients with asthma
The objective of this research proposal is to conduct a randomized placebo controlled trial of 4 weeks statin therapy in patients in moderate to severe but stable asthma We hypothesize that statins may directly reduce airway inflammation andor contribute to the anti-inflammatory effects of corticosteroid treatment in these patients We will measure the effects of statins by measuring airway sensitivity to methacholine pulmonary function sputum eosinophils and quality of life in subjects with asthma after 4 weeks of treatment Statins may become an alternative treatment option or act as steroid sparing agents in patients with asthma
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None