Ignite Creation Date:
2024-05-05 @ 9:36 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00000646
Status:
COMPLETED
Last Update Posted:
2021-11-02
First Post:
1999-11-02
Brief Title:
Pentoxifylline Trental as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institute of Allergy and Infectious Diseases NIAID
Study Overview
Official Title:
Pentoxifylline Trental as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS
Status:
COMPLETED
Status Verified Date:
2021-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine whether pentoxifylline lowers tumor necrosis factor TNF levels in AIDS patients Pentoxifylline decreases tumor necrosis factor TNF and therefore should decrease such TNF-intensified events as cachexia enhanced HIV expression and inhibition of zidovudine AZT activity
Detailed Description:
Pentoxifylline decreases tumor necrosis factor TNF and therefore should decrease such TNF-intensified events as cachexia enhanced HIV expression and inhibition of zidovudine AZT activity
Twenty-seven AIDS patients with elevated TNF and less than 300 CD4 cells are given pentoxifylline 3 times a day for 8 weeks If no significant changes are seen in virologic immunologic or related measures 27 additional patients are given a higher dose of pentoxifylline 3 times a day for eight weeks
Twenty-seven AIDS patients with elevated TNF and less than 300 CD4 cells are given pentoxifylline 3 times a day for 8 weeks If no significant changes are seen in virologic immunologic or related measures 27 additional patients are given a higher dose of pentoxifylline 3 times a day for eight weeks
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 11135 | REGISTRY | DAIDS ES Registry Number | None |