Ignite Creation Date:
2024-05-05 @ 4:43 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00302419
Status:
COMPLETED
Last Update Posted:
2008-08-01
First Post:
2006-03-13
Brief Title:
Effect of Complementary Intracoronary Streptokinase Administration Immediately After Primary Percutaneous Coronary Intervention on Microvascular Perfusion and Late Term Infarct Size in Patients With Acute Myocardial Infarction
Sponsor:
Istanbul University
Organization:
Istanbul University
Study Overview
Official Title:
Effect of Complementary Intracoronary Streptokinase Administration Immediately After Primary Percutaneous Coronary Intervention on Microvascular Perfusion and Late Term Infarct Size in Patients With Acute Myocardial Infarction
Status:
COMPLETED
Status Verified Date:
2008-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide further improvement in myocardial perfusion by dissolving microvascular thrombus in situ formed or embolized from proximal site spontaneous or following PCI and fibrin
Detailed Description:
Mechanical reperfusion for acute myocardial infarction AMI targets optimal revascularization of the epicardial artery but also aims at improved myocardial salvage The goal of reperfusion therapies has shifted to include reperfusion downstream at the level of capillary bed and it might be more appropriate that the hypothesis now be termed the time dependent open artery and open microvascular hypothesis Failure to achieve myocardial reperfusion despite the presence of a patent coronary artery has been termed the no-reflow phenomenon and attributed to microvascular dysfunction It has become apparent that clinical outcomes are not only associated with patency of the epicardial artery but also with patency of the microcirculation Persistent impairment of microcirculation is associated with poor clinical outcome Complete reperfusion in AMI settings necessitates reopening of the all consecutive vascular compartments all the way through the coronary circulation But embolization following percutaneous coronary intervention PCI and in situ microthrombi generation at the microvascular level makes this goal difficult to achieve For this reason mechanical intervention to the epicardial coronary artery with or without using distal protection wouldnt be enough to achieve ideal reperfusion at the ultimate microvascular level At this point it has become more evident that we need to develop more competent and feasible reperfusion strategies which can help us to achieve reperfusion as complete as possible at all levels
Hypothesis
Complementary intracoronary streptokinase administration to primary PCI may provide further improvement in myocardial perfusion by dissolving microvascular thrombus in situ formed or embolized from proximal site spontaneous or following PCI and fibrin Improvement in microvascular perfusion may translate into reduction in infarct size and improvement in left ventricular function at long term
Hypothesis
Complementary intracoronary streptokinase administration to primary PCI may provide further improvement in myocardial perfusion by dissolving microvascular thrombus in situ formed or embolized from proximal site spontaneous or following PCI and fibrin Improvement in microvascular perfusion may translate into reduction in infarct size and improvement in left ventricular function at long term
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None