Ignite Creation Date:
2024-05-05 @ 4:43 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00309855
Status:
COMPLETED
Last Update Posted:
2012-07-31
First Post:
2006-03-31
Brief Title:
Testosterone-Driven Growth-Hormone GH Secretion in Aging Men
Sponsor:
Mayo Clinic
Organization:
Mayo Clinic
Study Overview
Official Title:
Mechanisms of Testosterone-Driven Growth-Hormone GH Secretion in Aging Men Modulation of GHRH GHRP and Somatostatin Action by Estrogenic Versus Androgenic Steroids
Status:
COMPLETED
Status Verified Date:
2012-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is being done to understand how testosterone the major male sex hormone controls the pituitary glands secretion of growth hormone GH GH is an important metabolic hormone which controls sugar fat and protein use in the body and maintains muscle strength and bone calcium content Both testosterone and GH decline in older men The age-related fall in these hormones probably contributes to relative frailty reduced quality of life bone loss muscle wasting and impaired sexual function
Detailed Description:
Repletion of testosterone in older men drives pulsatile GH secretion via conjoint facilitation of feedforward by the primary secretagogues GHRH and GHRP and repression of feedback by the dominant inhibitor somatostatin and in corollary testosterone acts via aromatization to estradiol andor reduction to 5 alpha-dihydrotestosterone
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None