Ignite Creation Date:
2024-05-06 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 12:45 PM
Study NCT ID:
NCT03517852
Status:
COMPLETED
Last Update Posted:
2024-01-19
First Post:
2018-04-13
Brief Title:
Intravital Microscopy IVM in Patients With Peritoneal Carcinomatosis PC
Sponsor:
Mayo Clinic
Organization:
Mayo Clinic
Study Overview
Official Title:
Intravital Microscopy IVM in Patients With Peritoneal Carcinomatosis PC
Status:
COMPLETED
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate the tumor-associated vasculature of patients with peritoneal carcinomatosis or cancer that spreads along the inner abdominal lining The investigators will use a technology known as intravital microscopy IVM in order to visualize in real-time the tumor-associated vessels of peritoneal disease The IVM observations may determine if an individual patients tumor vessels would be amenable to receiving systemic therapy based on the functionality of the vessels
Detailed Description:
Primary objectives To determine the feasibility and clinical utility of performing HIVM in patients with peritoneal carcinomatosis during standard course of treatment cytoreductive surgery with hyperthermic intraperitoneal chemotherapy or CRS-HIPEC
Secondary objectives
1 Compare the microscopic observation of the tumor-associated vessels with normal tissue peritoneal surface in each individual subject
2 Correlate the microscopic observations of the tumor-associated vessels with pathologic grade of tumor implants
3 Correlate the microscopic observation of the microvasculature with tumor-specific and overall survival
Secondary objectives
1 Compare the microscopic observation of the tumor-associated vessels with normal tissue peritoneal surface in each individual subject
2 Correlate the microscopic observations of the tumor-associated vessels with pathologic grade of tumor implants
3 Correlate the microscopic observation of the microvasculature with tumor-specific and overall survival
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None