Ignite Creation Date:
2024-05-06 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 12:44 PM
Study NCT ID:
NCT03510585
Status:
COMPLETED
Last Update Posted:
2018-04-27
First Post:
2013-06-18
Brief Title:
Mucociliary Clearance Airway Inflammation and Nasal Symptoms in Urban Motorcycle-drivers
Sponsor:
University of Sao Paulo
Organization:
University of Sao Paulo
Study Overview
Official Title:
Mucociliary Clearance Airway Inflammation and Nasal Symptoms in Urban Motorcycle-drivers
Status:
COMPLETED
Status Verified Date:
2018-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Professionals working in polluted areas may present increased airways symptoms and dysfunction Rhinopharyngeal retrograde clearance RRC has been used to improve mucus clearance in infants with bronchitis and bronchiolitis Flushing the nasal cavity with saline S has been used to reduce nasal inflammation in rhinitis and sinupathies The aim of this study was to assess the effects of RRC and RRC plus S RRCS on the airways in professional motorcyclists Twenty-four male motorcyclists mean age 36 years were randomly assigned to RRC or RRCS Subjects were assessed at baseline and 15 days after interventions for airways assessments by saccharin test mucus contact angle cellularity in nasal lavage and airways symptoms with the use of SNOT-20 questionnaire Data were analyzed by nonparametric ANOVA for repeated measures with Bonferronis correction A passive nitrogen dioxide monitoring system was used to assess the mean personal air pollution exposure along the study period NO2 The association between NO2 and the airways outcomes was analyzed by Spearman correlation test At baseline the two groups were similar in clinical demographics and working aspects From them 100 had airways symptoms complaints and 33 had nasal MCC impairment After treatments both groups presented improvements in airways symptoms and nasal MCC However increased number of macrophages and ciliated cells were observed in nasal lavage of both groups No associations between nitrogen dioxide and the outcome variables were detected Rhinopharyngeal retrograde clearance seems to be useful in the clinical management of the upper airways symptoms and dysfunction in adults
Detailed Description:
The nonsmokers subjects aged 18 years to 45 years were enrolled in this study after agreement with the written informed consent Subjects were randomly assigned to 15-days of one of the following interventions RRC and RRCS Non pharmacological respiratory approaches may be useful in the management of the respiratory symptoms and dysfunctions air pollution-related The purpose of this study was to determine whether saline instillation andor retrograde rhinopharyngeal retrograde clearance are effective in the treatment of upper airways dysfunction through nasal mucociliary clearance mucus properties pH cellularity and cytokines in nasal lavage and pH in exhaled breath condensate as well as the airways symptoms cough wheeze runny nose hoarseness among others in motorcyclists due to urban air pollution
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None