Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006408
Status:
COMPLETED
Last Update Posted:
2014-03-28
First Post:
2000-10-12
Brief Title:
Hypertension in Black Americans A Life Course Approach
Sponsor:
Duke University
Organization:
Duke University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2014-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the relationship between life-stress factors associated with socioeconomic conditions and hypertension
Detailed Description:
BACKGROUND
Increasingly researchers are recognizing that risk for cardiovascular disease CVD in adulthood is rooted in the social and material life conditions of childhood and that these childhood conditions may predict risk for CVD above and beyond traditional adulthood indicators of socioeconomic status SES such as education occupation or income Nowhere is this life course perspective on CVD risk more important than in the case of African Americans especially the generation that came of age in the US South in the late 1950s and 1960s the peak years of the modern Civil Rights Movement While some African American members of this age cohort were able to take advantage of the new opportunities for economic advancement some others were not resulting thereafter in different life course trajectories of exposure to social and economic hardship The relationship between variations in these social and economic life course trajectories and CVD risk specifically hypertension in adulthood has not been investigated in African Americans
DESIGN NARRATIVE
The study uses the Pitt County NC cohort a community sample of African Americans N1784 66 percent female 80 percent response rate who were between 25-50 years of age at baseline in 1988 Normotensives in the baseline sample were re-examined in 1993 N1195 66 percent female 85 percent response rate In addition to measuring blood pressure extensive data on psychosocial behavioral and anthropometric characteristics were obtained at both times The study re-examines the original cohort in 2001 the anticipated sample size is 1142 individuals 717 women and 425 men Starting from age 20 respondents reported exposure to three domains of socioenvironmental stressors will be assessed 1 adverse socioeconomic conditions 2 low levels of social integration and 3 racial discrimination Taken individually and then collectively the greater the cumulative life course exposure to these stressors the greater the risk for adult hypertension is expected to be The primary analyses will focus on the relationship between pre-1988 exposures and 1988 blood pressure status retrospective analyses and the relationship between pre-1988 exposures and changes in blood pressure status between 1988 and 2001prospective analyses
Increasingly researchers are recognizing that risk for cardiovascular disease CVD in adulthood is rooted in the social and material life conditions of childhood and that these childhood conditions may predict risk for CVD above and beyond traditional adulthood indicators of socioeconomic status SES such as education occupation or income Nowhere is this life course perspective on CVD risk more important than in the case of African Americans especially the generation that came of age in the US South in the late 1950s and 1960s the peak years of the modern Civil Rights Movement While some African American members of this age cohort were able to take advantage of the new opportunities for economic advancement some others were not resulting thereafter in different life course trajectories of exposure to social and economic hardship The relationship between variations in these social and economic life course trajectories and CVD risk specifically hypertension in adulthood has not been investigated in African Americans
DESIGN NARRATIVE
The study uses the Pitt County NC cohort a community sample of African Americans N1784 66 percent female 80 percent response rate who were between 25-50 years of age at baseline in 1988 Normotensives in the baseline sample were re-examined in 1993 N1195 66 percent female 85 percent response rate In addition to measuring blood pressure extensive data on psychosocial behavioral and anthropometric characteristics were obtained at both times The study re-examines the original cohort in 2001 the anticipated sample size is 1142 individuals 717 women and 425 men Starting from age 20 respondents reported exposure to three domains of socioenvironmental stressors will be assessed 1 adverse socioeconomic conditions 2 low levels of social integration and 3 racial discrimination Taken individually and then collectively the greater the cumulative life course exposure to these stressors the greater the risk for adult hypertension is expected to be The primary analyses will focus on the relationship between pre-1988 exposures and 1988 blood pressure status retrospective analyses and the relationship between pre-1988 exposures and changes in blood pressure status between 1988 and 2001prospective analyses
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL065645 | NIH | None | httpsreporternihgovquickSearchR01HL065645 |