Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00000661
Status:
COMPLETED
Last Update Posted:
2008-08-04
First Post:
1999-11-02
Brief Title:
The Pharmacokinetics of Zidovudine and Oxazepam Alone and in Combination in the HIV-Infected Patient
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institute of Allergy and Infectious Diseases NIAID
Study Overview
Official Title:
The Pharmacokinetics of Zidovudine and Oxazepam Alone and in Combination in the HIV-Infected Patient
Status:
COMPLETED
Status Verified Date:
1994-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine if a pharmacokinetic blood level interaction exists between zidovudine AZT and oxazepam in the HIV-infected patient Benzodiazepines such as oxazepam are among the most frequently prescribed class of drugs and are commonly used therapeutically for patients with chronic disease This study is important because of the potential for toxicity resulting from a reaction between AZT and benzodiazepines and the likelihood of frequent use of the combination of these drugs in patients with HIV infection
Detailed Description:
Benzodiazepines such as oxazepam are among the most frequently prescribed class of drugs and are commonly used therapeutically for patients with chronic disease This study is important because of the potential for toxicity resulting from a reaction between AZT and benzodiazepines and the likelihood of frequent use of the combination of these drugs in patients with HIV infection
Patients are studied to determine oral and intravenous AZT and single oral dose oxazepam pharmacokinetics Patients then take AZT and oxazepam together to determine if interactions between the drugs occur
Patients are studied to determine oral and intravenous AZT and single oral dose oxazepam pharmacokinetics Patients then take AZT and oxazepam together to determine if interactions between the drugs occur
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: