Ignite Creation Date:
2024-05-06 @ 11:36 AM
Last Modification Date:
2024-10-26 @ 12:47 PM
Study NCT ID:
NCT03556423
Status:
COMPLETED
Last Update Posted:
2022-05-27
First Post:
2018-05-16
Brief Title:
Neurophysiological Mechanisms Involved in Knee Osteoarthritis
Sponsor:
Université de Sherbrooke
Organization:
Université de Sherbrooke
Study Overview
Official Title:
Pain in Individuals With Knee Osteoarthritis Beyond the Joint and the Musculoskeletal System
Status:
COMPLETED
Status Verified Date:
2022-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Introduction Total knee arthroplasty TKA is an effective intervention to relieve people with osteoarthritis OA Nevertheless 15 to 30 of patients continue to experience severe pain following surgery Recent data suggest that central nervous system CNS changes may play a role in OA pain and possibly explain why some patients have poorer clinical outcomes following TKA Objectives Our main objectives are to explore the relationship between OA pain and 1 the integrity of corticospinal system 2 the efficacy of descending pain inhibition circuits Methods Fifty-two patients waiting for TKA will be recruited The integrity of the corticospinal projections will be measured using transcranial magnetic stimulation recruitment curve of the affected quadriceps femoris muscle and the descending pain inhibition circuits bulbospinal projections will be assessed by a counter-irritation paradigm ie conditioned pain modulation with immersion of the arm in painfully cold water Diffuse tension imaging DTI will also be used to quantify the strength of these corticospinal and bulbospinal projections Clinical outcomes will be evaluated before and after arthroplasty with a series of validated questionnaires such as the WOMAC Scale the McGill Pain Questionnaire and the Brief Pain Inventory These different neurophysiological and clinical measures will be taken before surgery 6 months after surgery and 1 year post-surgery Anticipated results The investigators expect a moderate association between pain and the strength of the corticospinal and bulbospinal projections Moreover it is expected that there will be a moderate association between the strength of the corticospinalbulbospinal projections and the clinical evolution of patients
Detailed Description:
See outcome measures
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None