Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005658
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-05-09
Brief Title:
Glycine to Treat Psychotic Disorders in Children
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Childhood Onset Psychotic Disorders An Open Trial With the Amino Acid Glycine
Status:
COMPLETED
Status Verified Date:
2002-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will test the safety and effectiveness of the amino acid glycine in treating psychotic disorders in children The drug will be given as an adjunct in addition to the patients current antipsychotic medication
Children age nine to 18 with schizophrenia or schizoaffective disorder whose symptoms began before age 13 may be eligible for this 10-week study Patients will be hospitalized during the course of the trial Weekend visits home may be permitted
Children enrolled in the study will be evaluated during a two-week pre-treatment period with written tests for IQ and academic functioning and with a magnetic resonance imaging MRI scan of the brain For the MRI the child lies on a table that slides into a large donut-shaped machine with a strong magnetic field This procedure produces images of the brain that may help identify brain abnormalities in schizophrenia that develop in childhood
During the eight-week treatment phase patients will receive glycine powder dissolved in water once a day in addition to their other antipsychotic medications They will undergo the following additional procedures during the course of treatment
1 Comprehensive psychiatric examination
2 Blood pressure and pulse monitoring once a week
3 Blood tests every other week - About one ounce of blood is drawn per week to measure glycine levels
4 Eye movement study at week eight - Using a technique called infrared oculography special detectors measure infrared light reflected off the childs eyes while he or she watches a moving square on a video monitor
5 Lumbar puncture spinal tap once during the study - About one-half ounce of cerebrospinal fluid the fluid surrounding the brain and spinal cord is withdrawn through a needle placed in the lower part of the spine for analysis of brain chemicals
Patients who respond well may continue to receive glycine treatment through their referring physician after the study is completed
NIMH will follow patients by phone every six months and with visits at two-year intervals
Children age nine to 18 with schizophrenia or schizoaffective disorder whose symptoms began before age 13 may be eligible for this 10-week study Patients will be hospitalized during the course of the trial Weekend visits home may be permitted
Children enrolled in the study will be evaluated during a two-week pre-treatment period with written tests for IQ and academic functioning and with a magnetic resonance imaging MRI scan of the brain For the MRI the child lies on a table that slides into a large donut-shaped machine with a strong magnetic field This procedure produces images of the brain that may help identify brain abnormalities in schizophrenia that develop in childhood
During the eight-week treatment phase patients will receive glycine powder dissolved in water once a day in addition to their other antipsychotic medications They will undergo the following additional procedures during the course of treatment
1 Comprehensive psychiatric examination
2 Blood pressure and pulse monitoring once a week
3 Blood tests every other week - About one ounce of blood is drawn per week to measure glycine levels
4 Eye movement study at week eight - Using a technique called infrared oculography special detectors measure infrared light reflected off the childs eyes while he or she watches a moving square on a video monitor
5 Lumbar puncture spinal tap once during the study - About one-half ounce of cerebrospinal fluid the fluid surrounding the brain and spinal cord is withdrawn through a needle placed in the lower part of the spine for analysis of brain chemicals
Patients who respond well may continue to receive glycine treatment through their referring physician after the study is completed
NIMH will follow patients by phone every six months and with visits at two-year intervals
Detailed Description:
The ability of glycine to potentiate the NMDA receptor-complex along with the fact that it is well tolerated in short-and long-term administration has raised the possibility that it may provide an effective treatment of augmentation for neuroleptic-resistant negative symptoms of schizophrenia Up to ten children and adolescents ages 9-18 meeting DSM-IV criteria for schizophrenia schizoaffective disorder and psychotic disorder not otherwise specified with onset of psychosis by age 12 who have failed at least two prior antipsychotics entering this protocol on their current antipsychotic medications will participate in an open 8-week trial of adjunctive glycine therapy In addition to the potential benefits if glycine therapy ameliorates enduring negative symptoms of schizophrenia we anticipate that recruiting these rare patients will be facilitated by the availability of this new treatment
This study will provide pilot data regarding the beneficial effects and safety of adjunctive glycine therapy for children and adolescents with treatment refractory psychotic disorders The availability of newer alternate treatments is also important for recruitment of patients in the broader study of the neurobiology and genetics of very early onset schizophrenia
Children and adolescents ages nine to eighteen will be allowed into the study Subjects entering the protocol as new patients will be characterized by clinical phenomenology eye tracking MRI brain imaging cerebrospinal fluid plasma and urinary biochemistry and chromosomal analysis Patients with prominent mood symptoms who have required the addition of mood stabilizing agents such as lithium or valproic acid will be allowed to remain on these medications for the duration of the treatment trial if clinically indicated Liver chemistries will be checked at baseline and at the end of the study
All first-degree relatives are interviewed in person and undergo eye tracking measurement and contribute blood cell lines as part of a genetic study of the cohort 84-M-0050
This study will provide pilot data regarding the beneficial effects and safety of adjunctive glycine therapy for children and adolescents with treatment refractory psychotic disorders The availability of newer alternate treatments is also important for recruitment of patients in the broader study of the neurobiology and genetics of very early onset schizophrenia
Children and adolescents ages nine to eighteen will be allowed into the study Subjects entering the protocol as new patients will be characterized by clinical phenomenology eye tracking MRI brain imaging cerebrospinal fluid plasma and urinary biochemistry and chromosomal analysis Patients with prominent mood symptoms who have required the addition of mood stabilizing agents such as lithium or valproic acid will be allowed to remain on these medications for the duration of the treatment trial if clinically indicated Liver chemistries will be checked at baseline and at the end of the study
All first-degree relatives are interviewed in person and undergo eye tracking measurement and contribute blood cell lines as part of a genetic study of the cohort 84-M-0050
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-M-0122 | None | None | None |